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FLASH GENE
Symbol WDR24 contributors: mct - updated : 28-06-2017
HGNC name WD repeat domain 24
HGNC id 20852
Location 16p13.3      Physical location : 734.701 - 740.400
Synonym name chromosome 16 open reading frame 21
Synonym symbol(s) C16orf21, DKFZp434F054, JFP7
DNA
TYPE functioning gene
STRUCTURE 5.70 kb     9 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 3165 - 790 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • WD repeat domain
    • HOMOLOGY
    Homologene
    FAMILY
  • WD repeat WDR24 family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • promotes lysosome acidification and autophagic flux in mammalian cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • WDR24 has both CRTC1 dependent and independent functions in the regulation of cellular metabolism
  • is a key effector of the GATOR2 complex, required for both CRTC1 activation and the CRTC1 independent regulation of lysosomes
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS