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FLASH GENE
Symbol WDR20 contributors: npt/mct - updated : 27-12-2018
HGNC name WD repeat domain 20
HGNC id 19667
Location 14q32.31      Physical location : 102.606.211 - 102.690.009
Synonym name DMR protein
Synonym symbol(s) DMR, MGC33177, FLJ33659, MGC33183
DNA
TYPE functioning gene
STRUCTURE 85.32 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 2597 63 581 - 2018 29655804
isoform 1
3 splicing 2423 62.7 569 - 2018 29655804
  • has an alternate 3' sequence
  • shorter isoform 2 with a distinct C terminus
  • 2 splicing 508 56 508 - 2018 29655804
  • lacking an in-frame exon in the coding region and having an alternate 3' sequence
  • isoform 3 lacking an internal segment
  • 4 - 2651 - 408 - 2018 29655804
    4 - 2595 - 396 - 2018 29655804
    4 - 2568 - 396 - 2018 29655804
    3 - 2475 - 396 - 2018 29655804
    5 - 2660 - 531 - 2018 29655804
    3 - 1178 - 86 - 2018 29655804
    5 - 2701 - 612 - 2018 29655804
    4 - 2349 - 324 - 2018 29655804
    4 - 1450 - 171 - 2018 29655804
    3 - 1348 - 161 - 2018 29655804
    3 - 2437 - 520 - 2018 29655804
    2 - 1165 - 100 - 2018 29655804
    7 - 2670 - 418 - 2018 29655804
    5 - 2710 - 591 - 2018 29655804
    5 - 2475 - 408 - 2018 29655804
    5 - 2516 - 408 - 2018 29655804
    4 - 2423 - 408 - 2018 29655804
    3 - 2240 - 408 - 2018 29655804
    3 - 2276 - 86 - 2018 29655804
    4 - 3102 - 195 - 2018 29655804
    4 - 2539 - 600 - 2018 29655804
    3 - 2482 - 581 - 2018 29655804
    4 - 4250 - 584 - 2018 29655804
    2 - 2285 - 520 - 2018 29655804
    4 - 2484 - 519 - 2018 29655804
    3 - 2463 - 438 - 2018 29655804
    2 - 2064 - 396 - 2018 29655804
    4 - 2340 - 396 - 2018 29655804
    5 - 2392 - 396 - 2018 29655804
    3 - 2247 - 396 - 2018 29655804
    3 - 2173 - 312 - 2018 29655804
    4 - 2266 - 312 - 2018 29655804
    3 - 1988 - 312 - 2018 29655804
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • five WD repeats
  • multiple WD40-repeats similar to WDR48
  • HOMOLOGY
    interspecies homolog to rattus Wdr20 (97.6pc)
    Homologene
    FAMILY
  • WD repeat containing gene family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    text
  • USP12/WDR48/WDR20 complex dynamically shuttles between the plasma membrane, cytoplasm and nucleus
  • basic FUNCTION
  • WD40-repeat containing protein, that is a common binding partner of WDR48, USP12, and USP46) (Kee 2010)
  • stimulated the enzymatic activity of USP12·WDR48, but not of USP1·WDR48 (Kee 2010)
  • not involved in regulating the FA pathway (Kee 2010)
  • acting as a cofactor that is required for the full enzymatic activity of the USP12·WDR48 DUB complex (Kee 2010)
  • serves as a stimulatory subunit for preserving and regulating the activity of the subset of the UAF1·USP complexes (Kee 2010)
  • potential importance of the USP12/WDR48/WDR20 complex in AR regulation and prostate cancer progression
  • new regulator of the ERAD machinery
  • plays a crucial role in as a "targeting subunit" that modulates CRM1-dependent shuttling of the USP12/WDR48/WDR20 complex between the plasma membrane, cytoplasm and nucleus
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of USP12·WDR48·WDR20 complex (potentially involved in other types of transcriptional regulation) (Kee 2010)
  • USP12/WDR481/WDR20 complex dynamically shuttles between the plasma membrane, cytoplasm and nucleus
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with USP12, USP48 (Kee 2010)
  • USP12, in complex with WDR48 and WDR20, deubiquitinates the AR to enhance receptor stability and transcriptional activity
  • USP12, in complex with WDR48 and WDR20, directly deubiquitinates and stabilises the AKT1 phosphatases PHLPP1 and PHLPP2 resulting in decreased levels of active AKT1
  • USP12 is known to require the co-factors WDR48 and WDR20 for catalytic activity
  • WDR48 and WDR20 interact with USP12 at two distinct sites far from its catalytic center
  • USP46 is regulated by two WD40-repeat (WDR) proteins, WDR48/UAF1 and WDR20
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    USP12 interacting partners WDR48 and WDR20 are potential therapeutic targets in prostate cancer
    ANIMAL & CELL MODELS