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FLASH GENE
Symbol WDR12 contributors: mct/npt - updated : 03/12/2008
HGNC name WD repeat domain 12
HGNC id 14098
Location 2q33.2      Physical location : 203.745.323 - 203.776.949
Synonym name YTM1 homolog
Synonym symbol(s) YTM1, FLJ10881, FLJ12719, FLJ12720
DNA
TYPE functioning gene
STRUCTURE 31.06 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
ALS2CR3 2q33 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 3 ALS2CR2 2q33-q34 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2 FLJ25351 2q33.2 hypothetical protein FLJ25351 ALS2CR4 2q33 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 4 MPP4 2q33.2 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) ALS2 2q33.2 amyotrophic lateral sclerosis 2 (juvenile) LOC151256 2q33.2 hypothetical LOC151256 ALS2CR7 2q33.2 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 7 FZD7 2q33 frizzled homolog 7 (Drosophila) FLJ39061 2q33.2 hypothetical protein FLJ39061 LOC339809 2q33.2 KIAA2012 protein UBL1 2q32.3-q33 ubiquitin-like 1 (sentrin) NOP5/NOP58 2q33.2 ubiquitin-like 1 (sentrin) BMPR2 2q33-q34 bone morphogenetic protein receptor, type II (serine/threonine kinase) FLJ38771 LOC130026 ALS2CR14 2q33 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 14 WDR12 2q33.2 WD repeat domain 12 ALS2CR8 2q33.2 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8 LOC130029 2q33.3 similar to CG1308-PA ALS2CR17 2q33.3 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 17 CYP20A1 2q33 cytochrome P450, family 20, subfamily A, polypeptide 1 ABI-2 2q33 abl-interactor 2 MRPL50P2 2q34 abl-interactor 2 RAPH1 2q33 Ras association (RalGDS/AF-6)and plekstrin homology 1 LOC344461 2q33.3 similar to ZNF207 protein CD28 2q33 CD28 antigen (Tp44) LOC344462 2q33.3 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) CTLA4 2q33 cytotoxic T-lymphocyte-associated protein 4 ICOS 2q33 inducible T-cell co-stimulator
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 1720 47.4 423 - Holzel (2005)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 pharynx   highly
Endocrinethyroid   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text pancreas
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven WD repats (TRP-ASP domain)
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be mediating protein-protein interactions
  • playing a crucial role for processing of the 32S precursor ribosomal RNA (rRNA) and cell proliferation
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • member of the Pes1-Bop1 complex (PeBoW complex, integrity of the PeBoW complex is required for ribosome biogenesis and cell proliferation in mammalian cells)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS