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FLASH GENE
Symbol WDR11 contributors: mct - updated : 25-10-2010
HGNC name bromodomain and WD repeat domain containing 2
HGNC id 13831
Corresponding disease
KAL7 idiopathic hypogonadotropic hypogonadism / Kallmann syndrome, WDR11 related
Location 10q26.12      Physical location : 122.610.686 - 122.669.038
Synonym name
  • WD repeat domain 11
  • WD repeat-containing protein 15
  • Synonym symbol(s) DR11, WDR15, KIAA1351, BRWD2, FLJ10506, FLJ42531, DKFZp434L1715
    DNA
    TYPE functioning gene
    STRUCTURE 58.34 kb     29 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    29 - 4746 136.7 1224 - 2001 11536051
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbraindiencephalonamygdala highly
    Olfactory (smell)olfactory bulb   highly
    Reproductivefemale systemovary  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve WD domains and nine of them (second through tenth) participate in the genesis of two consecutive beta propellers
  • a predicted transmembrane segment
  • a tyrosine phosphorylation site
  • HOMOLOGY
    Homologene
    FAMILY
  • WD repeat protein family
  • CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in tumorigenesis of glial tumors and other
  • potential player in the Sonic hedgehog-Patched-Gli-Emx signaling pathway via its interaction with EMX1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • WDR11, like WDR1, may form a dimer stabilized by interaction with two zinc ions
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with EMX1, a homeodomain transcription factor involved in the development of olfactory neurons
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) KAL7
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with ZNF230 in t(10;19) in glioblastoma
    tumoral        
    disrupted in glial tumor
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS