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FLASH GENE
Symbol WDR11 contributors: mct - updated : 25-10-2010
HGNC name bromodomain and WD repeat domain containing 2
HGNC id 13831
Corresponding disease
KAL7 idiopathic hypogonadotropic hypogonadism / Kallmann syndrome, WDR11 related
Location 10q26.12      Physical location : 122.610.686 - 122.669.038
Synonym name
  • WD repeat domain 11
  • WD repeat-containing protein 15
  • Synonym symbol(s) DR11, WDR15, KIAA1351, BRWD2, FLJ10506, FLJ42531, DKFZp434L1715
    DNA
    TYPE functioning gene
    STRUCTURE 58.34 kb     29 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC390007 10 similar to Mitochondrial import receptor subunit TOM22 homolog (Translocase of outer membrane 22 kDa subunit homolog) (hTom22) (1C9-2) C10orf46 10q26.12-q26.13 chromosome 10 open reading frame 46 LOC88066 10q26.13 similar to 60S ribosomal protein L17 (L23) NANOS1 10q26.13 nanos homolog 1 (Drosophila) EIF3S10 10q26 eukaryotic translation initiation factor 3, subunit 10 theta, 150/170kDa SFXN4 10q26.12 sideroflexin 4 PRDX3 10q25-q26 peroxiredoxin 3 GPRK5 10q24-qter G protein-coupled receptor kinase 5 RGS10 10q25 regulator of G-protein signalling 10 TIAL1 10q26.11 TIA1 cytotoxic granule-associated RNA binding protein-like 1 LOC119563 10q26.13 similar to 40S ribosomal protein S8 BAG3 10q25.2-q26.2 BCL2-associated athanogene 3 LOC93202 10q26.13 thioredoxin 1 pseudogene 2 INPP5F 10q26.13 inositol polyphosphate-5-phosphatase F FLJ13081 10q26.13 hypothetical protein FLJ13081 SEC23IP 10q25-q26 SEC23 interacting protein LOC338570 10q26.13 similar to alpha NAC/1.9.2. protein LOC196051 10q26.13 hypothetical protein LOC196051 WDR11 10q26 WD repeat domain 11 FGFR2 10q26 fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome) ATE1 10q26.13 arginyltransferase 1 FLJ20003 10q26.13 hypothetical protein FLJ20003 TACC2 10q26 transforming, acidic coiled-coil containing protein 2 FLJ25359 10q26.13 hypothetical protein FLJ25359 PLEKHA1 10q26.3 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 LOC387715 10 LOC387715 PRSS11 10q25.3-q26.2 protease, serine, 11 (IGF binding) LOC253436 10q26.13 hypothetical LOC253436 LOC390008 10 similar to hensin CUZD1 10q26.13 CUB and zona pellucida-like domains 1 MGC45962 10q26.13 hypothetical protein MGC45962 LOC118670 10q26.13 similar to hypothetical protein MGC45962 FLJ13490 10q26.13 hypothetical protein FLJ13490 MGC35392 10q26.13 hypothetical protein MGC35392 PEGASUS 10q26 zinc finger protein, subfamily 1A, 5 (Pegasus) ACADSB 10q25-q26 acyl-Coenzyme A dehydrogenase, short/branched chain
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    29 - 4746 136.7 1224 - 2001 11536051
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbraindiencephalonamygdala highly
    Olfactory (smell)olfactory bulb   highly
    Reproductivefemale systemovary  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve WD domains and nine of them (second through tenth) participate in the genesis of two consecutive beta propellers
  • a predicted transmembrane segment
  • a tyrosine phosphorylation site
  • HOMOLOGY
    Homologene
    FAMILY
  • WD repeat protein family
  • CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in tumorigenesis of glial tumors and other
  • potential player in the Sonic hedgehog-Patched-Gli-Emx signaling pathway via its interaction with EMX1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • WDR11, like WDR1, may form a dimer stabilized by interaction with two zinc ions
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with EMX1, a homeodomain transcription factor involved in the development of olfactory neurons
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) KAL7
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with ZNF230 in t(10;19) in glioblastoma
    tumoral        
    disrupted in glial tumor
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS