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FLASH GENE
Symbol WDFY2 contributors: mct - updated : 26-08-2010
HGNC name WD repeat and FYVE domain containing 2
HGNC id 20482
Location 13q14.3      Physical location : 52.158.483 - 52.336.170
Synonym name
  • zinc finger FYVE domain-containing protein 22
  • propeller-FYVE protein2
  • Synonym symbol(s) ZFYVE22, WDF2, RP11-147H23.1, PROF
    DNA
    TYPE functioning gene
    STRUCTURE 177.69 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    DLEU7 13q14.13 deleted in lymphocytic leukemia 7 FLJ11712 13q14.13 hypothetical protein FLJ11712 GUCY1B2 13q14.3 guanylate cyclase 1, soluble, beta 2 LOC387925 13 LOC387925 LOC341674 13q14.13 similar to ribosomal protein L5; 60S ribosomal protein L5 FLJ30707 13q14.13 hypothetical protein FLJ30707 DDX26 13q14.12-q14.2 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26 LOC220433 13q14.13 similar to ribosomal protein S4, X-linked WDFY2 13q14.12 WD repeat and FYVE domain containing 2 FLJ13639 13q14.2 hypothetical protein FLJ13639 FLJ37307 13q14.2 hypothetical protein FLJ37307 DKFZP434K1172 13q14.2 hypothetical protein DKFZp434K1172 LOC387926 13 hypothetical gene supported by AF338231; BC030655 ATP7B 13q14.3 ATPase, Cu++ transporting, beta polypeptide (Wilson disease) KIAA0266 13q12.2-q13.3 KIAA0266 protein LOC387927 13 similar to BB049667 protein MGC75495 13q14.2 similar to Serine/threonine-protein kinase Nek1 (NimA-related protein kinase 1) NEK3 13q14.2-q21.1 NIMA (never in mitosis gene a)-related kinase 3 LOC387928 13 similar to mitochondrial ribosomal protein S31; imogen 38 TPTEps1 13q14.2 TPTE and PTEN homologous inositol lipid phosphatase pseudogene THSD1 13q14.13 thrombospondin, type I, domain 1 C13orf9 13q14.13 chromosome 13 open reading frame 9 CKAP2 13q14 cytoskeleton associated protein 2 LOC387929 13 LOC387929 LOC220115 13q14.2 TPTE pseudogene LOC144983 13q14.2 hypothetical protein LOC144983 SUGT1 13q14.2 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) LECT1 13q14-q21 leukocyte cell derived chemotaxin 1 LOC121981 13q14.2 similar to peptidyl-Pro cis trans isomerase
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 3809 - 400 - Hayakawa (2006)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemplacenta   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven WD repeats, presumably forming a beta-propeller,
  • a domain identified in Fab1p, YOTB, VAC1p, and EEA1 (FYVE) domain,
  • a FYVE zinc finger domain
    HOMOLOGY
    interspecies homolog to murine Wdfy2
    homolog to rattus LOC305956
    Homologene
    FAMILY
    CATEGORY adaptor , chaperone/stress , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    text localized to a distinct subset of early endosomes, which are localized close to the plasma membrane (Walz 2010)
    basic FUNCTION
  • important, conserved role of WDFY2 in endocytosis (Hayakawa 2006)
  • adaptor protein that brings together a kinase with its substrate (Fritzius 2007)
  • acting as a scaffold that enables specificity of insulin signaling through AKT2 (Walz 2010)
  • may have a specific role in modulating signaling through Akt downstream of the interaction of this kinase with APPL1 (Walz 2010)
  • serves as a molecular scaffold that enables signaling specificity, demonstrating a mode of regulation that distinguishes between AKT1 and AKT2 (Walz 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • ion Zn2+ binding
  • protein
  • preferential interaction between WDFY2 and AKT2, that promotes the maintenance of AKT2 protein levels (Walz 2010)
  • VAMP2 is interaction partner (with VAMP2, may be involved in vesicle cycling in various secretory pathway) (Fritzius 2007)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS