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FLASH GENE
Symbol WDFY1 contributors: mct - updated : 18-05-2017
HGNC name WD repeat and FYVE domain containing 1
HGNC id 20451
Location 2q36.1      Physical location : 224.740.065 - 224.810.052
Synonym name phosphoinositide-binding protein SR1
Synonym symbol(s) WDF1, FENS-1, ZFYVE17, FENS-1, WDF1, ZFYVE17
DNA
TYPE functioning gene
STRUCTURE 70.04 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
EPHA4 2q36.1 EphA4 LOC130600 2q36.1 similar to ribosomal protein L23 LOC266724 2q36.3 heat shock 70kDa protein 9B pseudogene PAX3 2q36.1-q36.2 paired box gene 3 (Waardenburg syndrome 1) FLJ32447 2q36.1 hypothetical protein FLJ32447 SGPP2 2q36.3 sphingosine-1-phosphate phosphotase 2 FARSLB 2q36.1-q36.2 phenylalanine-tRNA synthetase-like, beta subunit DGAT2L1 2q36.3 diacylglycerol O-acyltransferase 2 like 1 LOC391486 2 similar to ribosomal protein L31 FACL3 2q34 fatty-acid-Coenzyme A ligase, long-chain 3 KCNE4 2q36.3 potassium voltage-gated channel, Isk-related family, member 4 SCG2 2q35-q36 secretogranin II (chromogranin C) LOC391487 2 similar to transcription factor-like protein 4 isoform beta; MAX-like bHLHZIP protein; MAX-like protein X; BigMax protein AP1S3 2q36.3 adaptor-related protein complex 1, sigma 3 subunit WDFY1 2q36.2 WD repeat and FYVE domain containing 1 MRPL44 2q36.3 mitochondrial ribosomal protein L44 SERPINE2 2q33-q35 serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 LOC391488 2 similar to Ubiquitin carboxyl-terminal hydrolase 21 (Ubiquitin thiolesterase 21) (Ubiquitin-specific processing protease 21) (Deubiquitinating enzyme 21) (NEDD8-specific protease) FLJ22746 2q36.3 hypothetical protein FLJ22746 CUL3 2q36.3 cullin 3 DOCK10 2q24.1-q36.3 dedicator of cytokinesis 10 KIAA1486 2q36.3 KIAA1486 protein IRS1 2q36 insulin receptor substrate 1 DKFZp547E052 2q36.3 hypothetical protein DKFZp547E052 COL4A4 2q35-q37.1 collagen, type IV, alpha 4 COL4A3 2q37.1 collagen, type IV, alpha 3 (Goodpasture antigen) LOC389077 2 LOC389077 GL004 2q37.1 LOC389077 FLJ22800 2q36.3 hypothetical protein FLJ22800 HRB 2q36 HIV-1 Rev binding protein DKFZp547H025 2q36.3 hypothetical protein DKFZp547H025 LOC389078 2 hypothetical gene supported by AK125767 SLC19A3 2q37 solute carrier family 19, member 3 CCL20 2q35-q36 chemokine (C-C motif) ligand 20
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 4682 - 410 - 2015 25736436
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Skin/Tegumentskin    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a single FYVE domain
  • seven WD40 repeats
  • HOMOLOGY
    interspecies homolog to murine Wdfy1
    homolog to rattus LOC301549
    Homologene
    FAMILY
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • may mediate the recruitment of protein involved in membrane trafficking and cell signaling to phoshatidylinositol-3-phosphate-containing membrane
  • crucial role for WDFY1 in bridging the TLR-TICAM1 interaction, which is necessary for TLR signaling
  • WDFY1 functioned downstream of NRP2 to promote endosome maturation, thereby influencing the endosomal trafficking of EGFR and the formation of autolysosomes responsible for the degradation of internalized cargo
  • NRP2 maintains an optimum concentration of WDFY1 by negatively regulating its expression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • TRIF signaling is a truly homeostatic pathway to maintain intestinal epithelial barrier function revealing fundamental differences in the innate immune signaling between mucosal homeostasis and tissue repair
  • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    ion Zn2+ binding
    protein
  • WDFY1 is a crucial adaptor protein in the TLR3/4 signaling pathway
  • WDFY1 recruits the signaling adaptor TICAM1 to TLR3 and TLR4, thereby potentiating signaling from these pattern recognition receptors (PRRs)
  • NRP2 maintains an optimum concentration of WDFY1 by negatively regulating its expression
  • NRP2 inhibits WDFY1 transcription by preventing the nuclear localization of a transcription factor, BPTF
  • cell & other
    REGULATION
    Other regulation of WDFY1 transcription by NRP2 axis is a critical event in maintaining metastatic phenotype in cancer cells
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS