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FLASH GENE
Symbol WBP2NL contributors: mct/npt - updated : 10-04-2010
HGNC name WBP2 N-terminal like
HGNC id 28389
Location 22q13.2      Physical location : 42.394.728 - 42.424.475
Synonym name
  • postacrosomal sheath WW domain-binding protein
  • WW domain-binding protein 2-like
  • Synonym symbol(s) PAWP, FLJ26145, MGC26816
    DNA
    TYPE functioning gene
    STRUCTURE 29.75 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2330 - 309 - Wu (2007)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  moderately
     stomach   moderately
    Reproductivefemale systembreastmammary gland highly
     female systemovary  moderately
     male systemtestis  highly
    Respiratoryrespiratory tracttrachea  moderately
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatozoa
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a GRAM domain
  • WW-binding
  • HOMOLOGY
    interspecies homolog to murine Wbp2nl (67.3 pc)
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nuclear envelope
    text
  • perinuclear theca of mature spermatozoa
  • resides in the postacrosomal sheath (PAS) of the sperm perinuclear theca (PT) (Wu 2008)
  • resident perinuclear theca protein (Oko 2009)
  • basic FUNCTION
  • may play a role in meiotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization
  • promotes meiotic resumption and pronuclear development during fertilization (Wu 2007)
  • is independent of acrosome formation and dependent on microtubular manchette transport (Wu 2007)
  • initiates intracellular calcium signaling, which is considered essential for oocyte activation, and is a primary initiator of zygotic development (Aarabi 2010)
  • enters the oocyte during fertilization and induces oocyte activation events including meiotic resumption, pronuclear formation, and egg cleavage (Aarabi 2010)
  • CELLULAR PROCESS cell cycle,division,meiosis
    PHYSIOLOGICAL PROCESS reproduction/sex
    text
  • egg activation
  • male pronucleus formation
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS