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FLASH GENE
Symbol WBP2 contributors: mct - updated : 29-03-2023
HGNC name WW domain binding protein 2
HGNC id 12738
Corresponding disease
DFNB107 deafness, autosomal recessive 107
Location 17q25      Physical location : 73.841.780 - 73.851.501
Synonym symbol(s) WBP-2, MGC18269, DFNB107, GRAMD6,
DNA
TYPE functioning gene
STRUCTURE 10.74 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1944 - 261 - 2004 14531730
9 - 2175 - 261 - 2004 14531730
7 - 1724 - 216 - 2004 14531730
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly
 thymus   highly
Nervousbrain   highly
Skin/Tegumentskin   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a PY motif
  • GRAM domain
  • an intrinsic activation domain
  • one of three polyproline (PY) motifs of WBP2 is essential for its coactivation and intrinsic activation functions
  • PPXY-containing C-terminal region
  • HOMOLOGY
    interspecies homolog to murine Wbp2
    Homologene
    FAMILY
    CATEGORY adaptor , protooncogene , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • not a transcriptional co-activator of PAX8, but rather behaves as an adaptor molecule
  • specifically enhancing the transactivation functions of progesterone receptor (PR) and estrogen receptor (ER), whereas it did not have any significant effect on the androgen receptor, glucocorticoid receptor, or the activation functions of TP53
  • role of WBP2 and YAP1 as coactivators for ER and PR transactivation pathways
  • important role as a downstream component of the Salvador-Warts-Hippo (SWH) tissue growth-control pathway
  • tyrosine kinase substrate, activating estrogen receptor alpha (ESR1)/progesterone receptor (PR) transcription, and playing a role in breast cancer, via the Wnt pathway
  • roles for ITCH and WBP2 in regulating CD4 T cell proliferation, providing insight into how ITCH may prevent inflammation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • WW domain contained in YAP
  • binding to the WW domain of Yes kinase-associated protein by its PY motifs
  • interacting with PAX8
  • E6-associated protein interacting protein
  • interacting with YAP1 (YAP1 enhances progesterone receptor transactivation, but YAP1 coactivation function is absolutely dependent on WBP2)
  • interaction of WBP2 with TAZ is dependent on the WW domain of TAZ and the PPXY-containing C-terminal region of WBP2
  • acts as a transcriptional coactivator for ESR1 and progesterone receptor (PGR)
  • WBP2 is a target of the Hippo/MAP3K10, and MAP3K10 is identified as yet another rheostat in the regulation of WBP2 and its oncogenic function
  • oncogenic transcriptional co-factor that interacts, amongst others, with two other transcriptional co-activators, YAP1 and TAZ, in the Hippo pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNB107
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a biomarker for early detection, prognosis, and companion diagnostics in breast cancer
  • nuclear WBP2, as the main functional form of WBP2 after its activation, is a meaningful indicator for the diagnosis and prediction of breast cancer progression
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    therapeutic strategies to overcome Hippo defects in cancers through targeting WBP2
    cancerreproductivebreast
    is a promising target for breast cancer therapy
    ANIMAL & CELL MODELS