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FLASH GENE
Symbol WBP11 contributors: mct/npt - updated : 08-07-2010
HGNC name WW domain binding protein 11
HGNC id 16461
Location 12p12.3      Physical location : 14.939.413 - 14.956.401
Synonym name
  • Npw38-binding protein NpwBP
  • SH3 domain-binding protein SNP70
  • splicing factor, PQBP1 and PP1 interacting
  • Synonym symbol(s) NPWBP, SIPP1, DKFZp779M1063, SNP70, WBP-11
    DNA
    TYPE functioning gene
    STRUCTURE 16.99 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2690 - 641 - Huang 2009)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid   highly
    Nervousbrain    
    Reproductivefemale systemuteruscervix highly
     male systemtestis  highly
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningretinal pigment epithelium (RPE)  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • nuclear localization signal in the N-terminus ,
  • two distinct PP1-binding domains involving a RVXF (Arg-Val-Xaa-Phe) motif
  • proline-rich C-terminal domain required for its subnuclear targeting to the speckles and binding PQBP1
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Wbp11
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text
  • largely nuclear, but it accumulated in the cytoplasm following UV- or X-radiation
  • colocalized with mRNA splicing factors and intermediate filament containing perinuclear networks
  • basic FUNCTION
  • functioning as an mRNA factory in the nucleus
  • may function as a component of an mRNA factory in the nucleus
  • nucleocytoplasmic shuttling protein, implicated in pre-mRNA splicing, by nucleocytoplasmic shuttling
  • pre-mRNA splicing factor WBP11, is a protein ligand of PQBP1 (Nicolaescu 2008)
  • essential roles for PQBP1 and a binding partner, WBP11, in early development
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • PQBP1, WBP11 complex
  • component of the spliceosomes
  • WBP11-PQBP1-induced nuclear inclusions are distinct from the protein aggregates that are associated with polyglutamine diseases and represent dynamic nucleoplasmic heteropolymers of WBP11 and PQBP1 (Nicolaescu 2008)
  • one of the functional partners of PQBP1 from a potentially large repertoire of other signaling ligands
  • INTERACTION
    DNA binding to poly (rG) and G-rich single strand
    RNA
    small molecule
    protein
  • interacts with protein Ser/Thr phosphatase-1 (PP1) and with the polyglutamine-tract-binding protein 1 (PQBP1)
  • interacting with WBP4 (significantly, tandem WW domains of WBP4 are connected by a highly flexible region, enabling their simultaneous interaction with two proline-rich motifs of WBP11) (Huang 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS