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FLASH GENE
Symbol WAC contributors: mct - updated : 27-03-2017
HGNC name WW domain containing adaptor with coiled-coil
HGNC id 17327
Corresponding disease
DEL10PP chromosome 10p proximal deletions
Location 10p12.1      Physical location : 28.821.426 - 28.909.921
Synonym symbol(s) KIAA1844, Wwp4, FLJ31290, PRO1741, BM-016, MGC10753, bA48B24, 1110067P07Rik, DESSH
DNA
TYPE functioning gene
STRUCTURE 90.69 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 splicing 3422 71 647 - 2011 21329877
14 splicing 5835 - 602 - 2011 21329877
truncated isoform
13 splicing 2665 - 544 - 2011 21329877
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal WW domain containing a central block of three tyrosine residues, that recognizes RNA polymerase II
  • C terminal 30AA forming coiled-coil region
  • HOMOLOGY
    interspecies homolog to Drosophila cg8949
    Homologene
    FAMILY
  • WW domain-containing splicing factor family
  • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text
  • localizes to the Golgi as well as the nucleus
  • WAC is bound to the Golgi by GOLGA2
  • basic FUNCTION
  • mediating protein-protein interaction
  • is unnecessary for VCP-mediated ER membrane fusion
  • functional partner of RNF20/40
  • during gene transcription, WAC targets RNF20/40 to associate with RNA polymerase II complex for HIST2H2BB ubiquitination at active transcription sites, which regulates transcription
  • required for starvation-induced autophagy but also acts as a potential negative regulator of the ubiquitin-proteasome system
  • WAC is a regulator of energy-mediated MTOR activity
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with PKD1
  • interacts with RNF20/40 through its C-terminal coiled-coil region and promotes RNF20/40 s E3 ligase activity for HIST1H2BB ubiquitination
  • in Golgi membranes, WAC is involved in a complex containing VCPIP1 and VCP
  • WAC and GOLGA2 interact with the ATG8 homolog GABARAP and regulate its subcellular localization
  • GOLGA2 directly interacts with WAC, and this interaction is required for autophagy
  • WAC suppresses GOLGA2 binding to GABARAP, regulating starvation-induced centrosomal GABARAP delivery to the phagophore
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL10PP
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS