| basic FUNCTION
| antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system playing a crucial role in the hemostasis process |
|
; may reduce the immunogenicity of FVIII by inhibiting the uptake of F8 by antigen presenting cells, the first step in the development of an immune response against a foreign antigen (PMID :  |
|
pathogenetic role for VWF-platelet interaction in flow disturbance-induced venous thrombosis |
|
having function in endothelial cells |
|
required for platelet adhesion to sites of vessel injury, a process vital for both hemostasis and thrombosis |
|
large, multimeric plasma glycoprotein that critically mediates hemostasis at sites of vascular injury |
|
binds calcium at physiologic calcium concentrations and calcium stabilizes VWF A2 domain by accelerating refolding |
|
VWFpropeptide binding to mature VWF occurs in the circulation, which can regulate the hemostatic potential of VWF by reducing VWF binding to platelet GP1BA |
|
risk factor for bleeding and thrombosis |
|
platelet-vessel wall interaction is mediated by VWF, which thereby plays a major role in physiological hemostasis and thrombotic disease |
|
large, multimeric protein that regulates hemostasis by tethering platelets to the subendothelial matrix at sites of vascular damage |
|
is one of the most important proteins of the hemostatic systemand its multimeric state is essential for its natural function to guide platelets to sites of injury |
|
possible role of complementary mechanisms that are capable of modifying the thrombogenic potential of VWF |
|
large multidomain, multimeric glycoprotein that plays an essential role in regulating the balance between blood clotting and bleeding |
