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FLASH GENE
Symbol VWC2L contributors: mct - updated : 24-09-2013
HGNC name von Willebrand factor C domain containing protein 2-like
HGNC id 37203
Location 2q35      Physical location : 215.276.460 - 215.440.653
Synonym name
  • brorin-like
  • DNA
    TYPE functioning gene
    STRUCTURE 164.48 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 908 - 222 in murine kidney and brain 2012 22209847
  • Vwc2l-1
  • has a signal peptide and 2 cysteine-rich (CR) domains
  • is potentially associated with matrix mineralization
  • - - - - 139 in murine femur/calvaria, kidney and brain 2012 22209847
  • lacks a part of 2nd CR domain
  • - - - - 102 in murine lung and heart 2012 22209847
    lacks both CR domains
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   predominantly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two characteristic cysteine-rich (CR) domains commonly found in CKP family
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane,junction
    basic FUNCTION
  • secreted protein that promotes matrix mineralization by modulating Osterix expression likely through TGFB1 superfamily growth factor signaling pathway
  • its expression is associated with matrix mineralization in osteoblasts
  • potential modulatory role of this novel CKP in matrix mineralization
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS