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FLASH GENE

Symbol

VWC2

contributors: mct/npt - updated : 12-03-2010

HGNC name	von Willebrand factor C domain containing 2
HGNC id

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	7p12.2      Physical location : 49.813.256 - 49.952.138
Synonym name	brain-specific chordin-like protein
	brorin
Synonym symbol(s)	MGC131845, PSST739, UNQ739

DNA

TYPE	functioning gene
STRUCTURE	138.89 kb     4 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_198570 4 - 1918 NP_940972 - 325 - Koike (2007)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       predominantly

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	predominantly expressed in neural tissues in embryos (Koike 2007)

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a putative secreted signal sequence at its amino terminus
	two cysteine-rich domains in its core region (Koike 2007)

HOMOLOGY

Homologene

FAMILY

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	potentially involved in neural development (Miyake 2009)
	novel secreted BMP antagonist that potentially plays roles in neural development and functions (Koike 2007)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS