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FLASH GENE
Symbol VTI1B contributors: mct - updated : 28-04-2012
HGNC name vesicle transport through interaction with t-SNAREs homolog 1B (yeast)
HGNC id 17793
Location 14q24.1      Physical location : 68.117.868 - 68.141.602
Synonym name
  • vesicle-associated soluble NSF attachment protein receptor (v-SNARE)
  • vesicle transport v-SNARE protein Vti1-like 1
  • Synonym symbol(s) VTI1, VTI2, VTI1L, VT1B, VTI1-LIKE, v-SNARE, vti1-rp1
    DNA
    TYPE functioning gene
    STRUCTURE 23.73 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1357 - 232 - 2001 12067063
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivemale systemprostate   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective    
    cells
    SystemCellPubmedSpeciesStageRna symbol
     digestive
    cell lineage
    cell lines SV40 transformed fibroblasts clone
    fluid/secretion
    at STAGE
    physiological period ageing
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • helical region found in SNAREs
  • HOMOLOGY
    Homologene
    FAMILY
  • VTI1 family
  • CATEGORY receptor , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    text membrane protein type 4
    basic FUNCTION
  • vesicle docking
  • both VTI1B and STX6 function and have rate-limiting roles in TNFalpha trafficking and secretion
  • combinational SNARE proteins VAMP8 and VTI1B mediate the fusion of antimicrobial and canonical autophagosomes with lysosomes, an essential event for autophagic degradation
  • VTI1A, VTI1B, are involved in neuronal development
  • functions at late endosomes
  • CELLULAR PROCESS cell life, senescence
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text may be concerned with increased secretion of extracellular matrix and various cytokines associated with cellular senescence
    PATHWAY
    metabolism
    signaling
    a component
  • forms a snare complex with syntaxin 7, syntaxin 8 and endobrevin/VAMP-8 which functions in the homotypic fusion of late endosomes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CLINT1 binds to VTI1B, suggesting that it may be a VTI1B-selective adaptor
  • endosomal SNARE proteins physically and functionally interact with CFTR
  • interacting with STX11 (by regulating the availability of VTI1B, STX11 regulates trafficking steps between late endosomes, lysosomes and the cell surface in macrophages)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS