Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol VTA1 contributors: mct/npt - updated : 22-08-2009
HGNC name Vps20-associated 1 homolog (S. cerevisiae)
HGNC id 20954
Location 6q24.1      Physical location : 142.468.409 - 142.542.083
Synonym name
  • Myo12 protein
  • chromosome 6 open reading frame 55
  • SKD1 binding protein 1
  • dopamine-responsive protein DRG-1
  • vacuolar protein sorting-associated protein VTA1 homolog
  • homolog of mouse SKD1-binding protein 1
  • LYST-interacting protein 5
  • Synonym symbol(s) HSPC228, My012, C6orf55, LIP5, FLJ27228, DRG-1, DRG1, SBP1
    DNA
    TYPE functioning gene
    STRUCTURE 73.70 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 3273 34 307 - Ward (2005)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    Reproductivemale systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatum  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an ATP and actin domain at the N terminus
  • a nec with n copies of the IQ motif
  • a calmodulin calcium-binding region at the C terminus, mediating dimerization and both subunits are required for its function as a VPS4A regulator
  • HOMOLOGY
    Homologene
    FAMILY
  • myosin superfamily
  • VTA1 family
  • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    text predominantly a cytosolic protein (Ward 2005)
    basic FUNCTION
  • may contribute to the dopamine-induced cell growth, which is negatively regulated by NGFRAP1 (Yu 2007)
  • role for direct binding between VTA1 and ESCRT-III proteins (CHMP1B, CHMP2A, VPS24) that is likely to complement VTA1 previously described ability to regulate VPS4 activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • VTA1-CHMP5 complex (Bajorek 2009)
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP binding
  • protein
  • actin
  • interact with NGFRAP1, and the interaction occurred in cytoplasm (through N-terminus of VTA1 and the C-terminus of NGFRAP1 (Yu 2007)
  • interacting with CHMP5 (with CHMP5 function in multivesicular body sorting, whereas only VTA1 is required for HIV release) (Ward 2005)
  • VPS4A regulator (Xiao 2008)
  • binds to a different region within CHMP5 than within the other ESCRT-III proteins (Shim 2008)
  • interactions with ESCRT-III proteins may be regulated by ESCRT-III conformation (possible role for direct binding between VTA1 and ESCRT-III proteins that is likely to complement its previously described ability to regulate VPS4A and VPS4B activity) (Shim 2008)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS