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FLASH GENE
Symbol VSNL1 contributors: mct - updated : 26-03-2011
HGNC name visinin-like 1
HGNC id 12722
Location 2p24.3      Physical location : 17.721.806 - 17.837.705
Synonym name
  • hippocalcin-like protein 3
  • Synonym symbol(s) VILIP, HPCAL3, HLP3, HUVISL1, VILIP-1, VILIP1
    DNA
    TYPE functioning gene
    STRUCTURE 115.90 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    text structure
  • direct NRF1 binding to the VSNL1 promoter
  • MAPPING cloned Y linked Y status confirmed
    Physical map
    NAG 2p24.1 similar to 40S ribosomal protein S16 DDX1 2p24.1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 LOC130678 2p25.1 similar to 60S acidic ribosomal protein P1 NCYM 2p24.1 similar to 60S acidic ribosomal protein P1 MYCN 2p24.1 v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) LOC391353 2 similar to Cerebellar-degeneration-related antigen 1 (CDR34) DKFZP566A1524 2p24.3 hypothetical protein DKFZp566A1524 LOC391354 2 similar to Mothers against decapentaplegic homolog interacting protein (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP) LOC388925 2 hypothetical gene supported by BC018859; NM_002802 VSNL1 2p24.3 visinin-like 1 SMC6L1 2p24.3 SMC6 structural maintenance of chromosomes 6-like 1 (yeast) LOC388926 2 similar to RIKEN cDNA 5830483C08 gene FLJ40869 2p24.3 similar to RIKEN cDNA 5830483C08 gene LOC343930 2p24.3 similar to pMesogenin1 KCNS3 2p23-p22.2 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3 RDH14 2p24.1 retinol dehydrogenase 14 (all-trans and 9-cis) NT5C1B 2p24.1 5'-nucleotidase, cytosolic IB LOC388927 2 LOC388927 OSR1 3p22-p21.3 oxidative-stress responsive 1 LOC130500 2p24.3 similar to Uncharacterized hematopoietic stem/progenitor cells protein MDS029 LOC130502 2p24.3 similar to CG14894-PA KIAA1336 2p24.3 KIAA1336 protein MATN3 2p24-p23 matrilin 3 LAPTM4A 2p24.3 lysosomal-associated protein transmembrane 4 alpha LOC391355 2 similar to 40S ribosomal protein S16
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2014 - 191 - 1995 8530085
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart     Homo sapiens
    Nervousbrainhindbraincerebellum  
     brain   highly Homo sapiens
     brainlimbic systemhippocampus highly Homo sapiens
    Respiratoryrespiratory tractlarynx  highly
    Urinarykidney    
    Visualeyeretina   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Muscularmyocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • and an N-terminal myristoylation consensus sequence
  • four EF-hand calcium binding protein (EF1, EF2, EF3, and EF4), with a sequence CPXG in the first EF-hand that eliminates its capacity to bind Ca2+
  • HOMOLOGY
    interspecies homolog to rattus Rnvp1
    Homologene
    FAMILY
  • recoverin family, neuronal EF-hand calcium-sensor protein family
  • neuronal calcium sensor family of Ca2+-myristoyl switch proteins
  • CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • calcium sensor, likely involved in signal transduction
  • modulating intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase
  • playing a critical role in regulating cell adhesion and migration by downregulation of fibronectin receptor expression
  • regulates the cell surface localization of natriuretic peptide receptor B (NPR2)
  • regulates several neuronal signaling pathways implicated in synaptic plasticity, such as cyclic nucleotide cascades and nicotinergic signaling
  • important Ca2+ sensor for controlling neuronal excitability by modulating nicotinergic neurotransmission important for synaptic plasticity and disease processes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text CNS development
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    phosphotransduction
    a component
  • forms a dimer in solution independent of Ca2+ and myristoylation
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • myristoyl group
  • calcium Ca2+
  • binds functionally to Mg2+ at EF3 and binds cooperatively to Ca2+ at EF2 and EF3
  • protein
  • regulating the inhibition of Ca2+ dependent rhodopsin phosphorylation
  • binding NTRK2 mRNA
  • interacting with P2X2 receptors and displaying enhanced interactions in an activation- and calcium-dependent manner owing to exposure of its binding segment in P2X2 receptors
  • NRF1 could be a regulatory factor for VSNL1 gene expression and for other visinin-like subfamily members including HPCAL4, HPCAL1, HPCA, and NCALD
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS