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FLASH GENE
Symbol VRK3 contributors: mct - updated : 28-09-2016
HGNC name vaccinia related kinase 3
HGNC id 18996
Location 19q13.33      Physical location : 50.479.723 - 50.528.805
EC.number 2.7.11.1
DNA
TYPE functioning gene
STRUCTURE 49.48 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - D19S879 - D19S604 - VRK3 - D19S867 - D19S866 - qter
Authors UCSC (2009)
Physical map
FCGRT 19q13.3 Fc fragment of IgG, receptor, transporter, alpha RCN3 19q13.33 reticulocalbin 3, EF-hand calcium binding domain NOSIP 19q13.3 nitric oxide synthase interacting protein PRRG2 19q13.33 proline-rich Gla (G-carboxyglutamic acid) polypeptide 2 KIAA1205 19q13.33 KIAA1205 RRAS 19q13.3-q13.4 related RAS viral (r-ras) oncogene homolog SR-A1 19q13.3-q13.4 serine arginine-rich pre-mRNA splicing factor SR-A1 IRF3 19q13.3 interferon regulatory factor 3 BCL2L12 19q13.3 BCL2-like 12 (proline rich) HRMT1L2 19q13-3 HMT1 hnRNP methyltransferase-like 2 (S. cerevisiae) LOC199800 19q13.33 hypothetical protein LOC199800 CPT1C 19q13.33 hypothetical protein LOC199800 LOC388556 19 hypothetical gene supported by NM_001013 TSKS 19q13.3 hypothetical gene supported by NM_001013 AP2A1 19q13.3 adaptor-related protein complex 2, alpha 1 subunit FLJ22688 19q13.33 hypothetical protein FLJ22688 TCBAP0758 19q13.3 hypothetical protein TCBAP0758 PTOV1 19q13.33 prostate tumor over expressed gene 1 PNKP 19q13.3-q13.4 polynucleotide kinase 3'-phosphatase MGC2865 19q13.33 hypothetical protein MGC2865 FLJ12168 IL4I1 19q13.3-q13.4 interleukin 4 induced 1 NUP62 19q13.33 nucleoporin 62kDa ATF5 19q13.3 activating transcription factor 5 SIGLEC11 19q13.33 sialic acid binding Ig-like lectin 11 VRK3 19q13 vaccinia related kinase 3 ZNF473 19q13.33 zinc finger protein 473 LOC342917 19q13.33 similar to kruppel-related zinc finger protein MGC33947 19q13.33 hypothetical protein MGC33947 MYH14 19q13.33 myosin, heavy polypeptide 14
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 splicing 2129 52.8 474 - 2004 14645249
14 splicing 1979 47.7 424 - 2004 14645249
  • lacking an alternate in-frame exon in the 5' coding region compared to variant 1
  • 13 - 1902 - 412 - 2004 14645249
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
     liver    
    Lymphoid/Immunespleen    
     thymus    
    Reproductivefemale systemuteruscervix  
     female systemovary   
     male systemtestis   
    Skin/Tegumentskin    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a protein kinase domain
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Vrk3 (75.5 pc)
    homolog to murine Vrk3 (75.3 pc)
    Homologene
    FAMILY
  • protein kinase superfamily
  • CK1 Ser/Thr protein kinase family
  • VRK subfamily
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    text
  • VRK3 expression levels increase during interphase
  • basic FUNCTION
  • may be involved in protein amino acid phosphorylation
  • VRK3 still shares striking structural similarity with VRK2, and appears to be locked in a pseudoactive conformation
  • pseudokinase that is catalytically inactive due to changes in motifs that are essential for kinase activity
  • acts as an active kinase as well as a signaling scaffold in cells
  • kinase activity of VRK3 is involved in the regulation of the cell cycle
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • VRK3 enhances the phosphatase activity of DUSP3 by a mechanism independent of its kinase activity, and direct interaction of DUSP3 with VRK3 posttranslationally regulates ERK signalling
  • evidence for the role of bivalent cations in structural stabilities of VRK1, VRK2, VRK3
  • phosphorylates the nuclear envelope protein barrier-to-autointegration factor (BANF1) on Ser4
  • VRK3-mediated phosphorylation of BANF1 may facilitate DNA replication or gene expression by facilitating the dissociation of nuclear envelope proteins and chromatin during interphase
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerative 
    is a potential therapeutic target in neurodegenerative diseases.
    ANIMAL & CELL MODELS