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FLASH GENE
Symbol VRK2 contributors: mct - updated : 28-09-2013
HGNC name vaccinia related kinase 2
HGNC id 12719
Location 2p16.1      Physical location : 58.273.776 - 58.387.055
DNA
TYPE functioning gene
STRUCTURE 113.00 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site
MAPPING cloned Y linked   status provisional
Map pter - D2S119 - SLC3A1 - D2S288 - MSH2 , PIGF - FSHR - D2S123 - D2S378 - VRK2 - D2S2315 - D2S370 - D2S337 - cen
Authors Gene Map,Kirschner (99)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 2081 - 508 in all cell types Blanco (2006)
  • C-terminal hydrophobic region that anchors the protein to membranes in the endoplasmic reticulum (ER) and mitochondria
  • able to interact with MAP3K7 by its C-terminal region, forming stable complexes
  • - - - - 397 . in both the cytoplasm and the nucleus . in cell lines in which VRK1 is cytoplasmic Blanco (2006)
  • only overexpression of the nuclear VRK2B isoform induces TP53 stabilization by post-translational modification, largely due to Thr18 phosphorylation
  • may play a role in controlling the binding specificity of the N-terminal transactivation domain of TP53
  • EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine   highly
    Lymphoid/Immunelymph node   highly
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • catalytic N-terminal domain that phosphorylate TP53
  • a C-terminal hydrophobic region that anchors the protein to membranes in the endoplasmic reticulum (ER) and mitochondria, and it colocalizes with calreticulin, calnexin and mitotracker
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • modulates the stress response to hypoxia mediated by MAP3K7
  • show modest autophosphorylation activity and will also phosphorylate casein
  • VRK3 still shares striking structural similarity with VRK2, and appears to be locked in a pseudoactive conformation
  • inhibits mitogen-activated protein kinase signaling and inversely correlates with ERBB2 in breast cancer
  • VRK1 and VRK2 are atypical active Ser-Thr kinases implicated in control of cell cycle entry, apoptosis and autophagy, and affect signalling by mitogen activated protein kinases (MAPK)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    signalling pathway
    a component might be components of a new signalling pathway that is likely to play a role in normal cell proliferation
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts specifically with EBV BHRF1 and the interaction is involved in protecting cells from apoptosis
  • evidence for the role of bivalent cations in structural stabilities of VRK1, VRK2, VRK3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS