Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol VPS52 contributors: mct - updated : 29-08-2016
HGNC name vacuolar protein sorting 52 (yeast)
HGNC id 10518
Location 6p21.32      Physical location : 4.450.268 - 33.239.662
Synonym name
  • ARE-1 like
  • SAC2 suppressor of actin mutations 2-like (yeast)
  • Synonym symbol(s) ARE1L, ARE1, SAC1, RP5-1033B10, SACM2L, GARP
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head, opposite orientation
    text lying in a head to head orientation with the gene encoding ribosomal protein S18
    STRUCTURE 21.69 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status provisional
    Map pter - HLA-DPB2 - COL11A2 - RXRB - SLC39A7 - HSD17B8 - RING1 - VPS52 - RPS18 - C6orf11 - TAPBP - cen
    Authors Walter (98)
    Text see KE@
    Physical map
    HLA-DMA 6p21.3 major histocompatibility complex, class II, DM alpha BRD2 6p21.3 bromodomain containing 2 HLA-DOA 6p21.3 major histocompatibility complex, class II, DO alpha HLA-DPA1 6p21.3 major histocompatibility complex, class II, DP alpha 1 HLA-DPB1 6p21.3 major histocompatibility complex, class II, DP beta 1 RPL32P1 6p21.3 ribosomal protein L32 pseudogene 1 LOC391913 6 similar to MHC HLA-SX-alpha HLA-DPB2 6p21.3 major histocompatibility complex, class II, DP beta 2 (pseudogene) COL11A2 6p21.3 collagen, type XI, alpha 2 RXRB 6p21.3 retinoid X receptor, beta SLC39A7 6p21.3 solute carrier family 39 (zinc transporter), member 7 HSD17B8 6p21.3 hydroxysteroid (17-beta) dehydrogenase 8 RING1 6p21.3 ring finger protein 1 VPS52 6p21.3 vacuolar protein sorting 52 (yeast) B3GALT4 6p21.3 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 RPS18 6p21.3 ribosomal protein S18 C6orf11 6p21.3 chromosome 6 open reading frame 11 D6S2723E 6p21.3 DNA segment on chromosome 6 (unique, pseudogene) 2723 expressed sequence HKE2 6p21.3 HLA class II region expressed gene KE2 RAB2L 6p21.3 RAB2, member RAS oncogene family-like TAPBP 6p21.3 TAP binding protein (tapasin) ZNF297 6p21.3 zinc finger protein 297 DAXX 6p21.3 death-associated protein 6 LOC346177 6p21.31 similar to myosin:SUBUNIT=regulatory light chain LYPLA2P1 6p21.31 lysophospholipase II pseudogene 1 KIFC1 6p21.3 kinesin family member C1 PHF1 6p21.3 PHD finger protein 1 C6orf82 6pter-p21.31 chromosome 6 open reading frame 82
    regionally located identified in the centromeric part of MHC2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 initiation site 3046 82.2 723 - 2009 NP_072047
    19 initiation site 3442 75.1 656 - 2009 NP_072047
    lacks an internal segment
    20 - 2535 - 534 - 2009 NP_072047
    20 - 2727 - 598 - 2009 NP_072047
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    a putative coiled-coil region
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae suppressor of actin mutations 2 like (Sac2p)
    homolog to murine Vps52
    homolog to rattus Sacm2l
    Homologene
    FAMILY
    CATEGORY unknown/unspecified , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • docking protein
  • involving in actin and chitin localization
  • orchestrates retrograde transport from endosomes to the TGN by promoting vesicle tethering and assembly of SNARE complexes in consecutive, independent steps
  • involved in the retrograde trafficking of endosomes
  • required in the formation of embryonic structures at a later stage of development, revealing hitherto unknown functions of VPS52 in the development of a multicellular organism
  • acting through GARP, VPS52 participates in a membrane-related process of the microRNA pathway
  • Golgi-associated retrograde protein (GARP) complex, which functions in endosome-to-Golgi retrograde vesicular transport, as a critical player in sphingolipid homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text vesicular transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TSSC1 is required for efficient recruitment of GARP (composed of ANG2, VPS52, VPS53 and VPS54 subunits) to the TGN
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS