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FLASH GENE

Symbol

VPS4B

contributors: mct - updated : 04-06-2019

HGNC name	vacuolar protein sorting 4B (S. cerevisiae)
HGNC id	10895

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	18q21.33      Physical location : 61.056.426 - 61.089.752
Synonym name	suppressor of K+ transport defect 1
	cell migration-inducing 1
	protein SKD1
Synonym symbol(s)	MIG1, SKD1, VPS4-2

DNA

TYPE	functioning gene
STRUCTURE	33.33 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	multiple polyadenylation sites

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004869 11 - 3396 NP_004860 - 444 - -

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly   pharynx       highly Endocrine adrenal gland       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N-terminal MIT (microtubule interacting and trafficking) domain that may serve as an adapter for the ESCRT-III complex, involved in endosomal trafficking
	a coiled-coil region
	one AAA domain
	an ATP/GTP binding P-loop motif

HOMOLOGY

interspecies	homolog to murine Skd1(suppressor of K+ transport defect 1)
	ortholog to yeast S.cerevisiae vsp4 (vacuolar sorting protein 4)

Homologene

FAMILY

AAA ATPase family

CATEGORY

chaperone/stress , enzyme , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
text	localizes to centrosomes and midbodies in a cell cycle–dependent manner

basic FUNCTION	involved in intracellular protein transport probably out of a prevacuolar endosomal compartment
	may be involved in the release of components of the bilayered coat from the endosomal membrane
	AAA-ATPase involved in multivesicular body formation
	with VPS4A play the most critical roles in centrosome maintenance

CELLULAR PROCESS

protein

PHYSIOLOGICAL PROCESS

cellular trafficking transport

text	protein transport

PATHWAY

metabolism

signaling

ESCRT-III (CHMP) proteins pathhway

a component

forming heteromeric complex with VPS4A

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP binding

protein	interacts with ESCRT-III complex components CHMP1A, CHMP1B and CHMP2A
	CSNK2A1 is involved in the phosphorylation of the ESCRT-III subunits CHMP3 and CHMP2B, as well as of VPS4B/SKD1, an ATPase that mediates ESCRT-III disassembly

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS