Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

VPS45

contributors: mct - updated : 14-06-2011

HGNC name	vacuolar protein sorting 45 homolog (S. cerevisiae)
HGNC id	14579

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	SCNP5 neutropenia, severe congenital, 5
Location	1q21.3      Physical location : 150.039.341 - 150.117.504
Synonym name	vacuolar protein sorting 45B (yeast)
	vacuolar protein sorting protein similar to S. cerevisiae Vsp45p
	vacuolar protein sorting 45A (yeast)
Synonym symbol(s)	VSP45, VPS45B, VSP45A, H1VPS45, VPS45A, H1

DNA

TYPE	functioning gene
STRUCTURE	78.16 kb     15 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_007259 15 - 2817 65.1 570 - 1999 10404641

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       highly Cardiovascular heart         Reproductive male system testis     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Lymphoid         Muscular striatum cardiac

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic neutrophil

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to murine Vps45
	homolog to rattus Vps45a
	homolog to Drosophila Cg8228
	homolog to yeast S.cerevisiae Vps45p

Homologene

FAMILY	SEC1 domain family
	STXBP/UNC-18/SEC1 family

CATEGORY

motor/contractile , secretory , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,organelle,lysosome

basic FUNCTION	playing a role in trafficking proteins, including inflammatory mediators
	playing a role in segregation of intracellular molecules into distinct organelles
	essential for SNARE-mediated membrane trafficking
	key molecule that functions downstream from RAB5, cooperating with ZFYVE20, to regulate the dynamics of the endocytic system in multicellular organisms
	playing a role in Golgi-to-lysosome trafficking
	VPS45 and ZFYVE20 are implicated in post early endosome transport, and their interaction potentially serves as a nexus to promote bidirectional transport along the endosome-to-recycling compartment and endosome-to-Golgi axes

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

inflammation , cellular trafficking transport

text	vesicular transport, inflammatory response

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interact with its cognate SNARE proteins through distinct mechanisms at different stages in the SNARE assembly/disassembly cycle
	RBSN is a RAB5 effector that bridges an interaction between Rab5 and the Sec1/Munc18-family protein VPS45
	interacts with the divalent Rab4/Rab5 effector, ZFYVE20 and carries out multiple functions in the endocytic/secretory pathways

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SCNP5

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS