Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol VPS36 contributors: npt/ - updated : 14-04-2007
HGNC name vacuolar protein sorting 36 homolog (S. cerevisiae)
HGNC id 20312
Location 13q14.3      Physical location : 52.986.738 - 53.024.763
Synonym name
  • chromosome 13 open reading frame 9
  • ELL-associated protein, 45 kDa
  • ESCRT-II complex subunit VPS36
  • Synonym symbol(s) CGI-145, C13orf9, EAP45, DKFZp781E0871
    DNA
    TYPE functioning gene
    STRUCTURE 38.03 kb     14 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 4427 - 386 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumearinnercochlea highly
    Lymphoid/Immunelymph node   highly
    Nervousnervecranial nerve  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a GLUE domain (GRAM-like ubiquitin-binding in Eap45)
  • a split pleckstrin-homology domain that binds ubiquitin along one edge of the beta-sandwich
  • HOMOLOGY
    interspecies homolog to S. cerevisiae vps36
    Homologene
    FAMILY
  • VPS36 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lysosome
    intracellular,nucleus
    basic FUNCTION
  • playing a role in endosomal sorting of ubiquitinated cargo
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • VPS36, SNF8 and VPS25 form a complex ESCRT-II (endosomal sorting complex required for transport II)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS