protein
| binding to the coiled-coil containing domain of SNX1 |
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VPS26A, VPS29 |
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displayed binding to gephyrin |
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GLRB binds the trafficking proteins VPS35 and Neurobeachin (NBEA) |
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endosomal localization of FAM21C is VPS35 dependent and relies on multivalency of FAM21C repeat elements |
|
MAGEL2 was identified to interact with VPS35 and VPS26A two components of the endosomal retromer complex |
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VPS35 recruits MAGEL2-TRIM27 to retromer-positive endosomes by binding to MAGEL2 |
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suppression of VPS35 led to mistrafficking of the melanogenic enzymes, tyrosinase and TYRP1, establishing that retromer acts in concert with ANKRD27 in this trafficking pathway |
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interactions between VPS35, EIF4G1, and SNCA |
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VPS35 works as the central subunit of retromer to recognize the cargos and binds with VPS29 and VPS26A via distinct domains |
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VPS35 has a role in the lysosomal degradation of parkin substrate AIMP2, of which accumulation leads to poly(ADP-ribose) polymerase-1 (PARP1)-dependent cell death |
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KLF7/VPS35 axis contributes to hepatocellular carcinoma progression through CCDC85C-activated CTNNB1 pathway |