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FLASH GENE
Symbol VPS28 contributors: mct - updated : 04-06-2019
HGNC name vacuolar protein sorting 28 (yeast)
HGNC id 18178
Location 8q24.3      Physical location : 145.648.999 - 145.653.927
Synonym name yeast class E protein Vps28p homolog
Synonym symbol(s) CIIA
DNA
TYPE functioning gene
STRUCTURE 4.96 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC392276 8 similar to RIKEN cDNA 1700091F14 LOC392277 8 similar to RIKEN cDNA 1700091F14 KIAA1833 8q24.3 hypothetical protein KIAA1833 BOP1 8q24.3 block of proliferation 1 HSF1 8q24.3 heat shock transcription factor 1 DGAT1 8q24.3 diacylglycerol O-acyltransferase homolog 1 (mouse) DKFZp547F072 8q24.3 hypothetical protein DKFZp547F072 SCRT1 8q24.3 scratch homolog 1, zinc finger protein (Drosophila) LOC340393 8q24.3 similar to unnmaed protein product FBXL6 8q24-q25 F-box and leucine-rich repeat protein 6 FLJ11856 8q24.3 putative G-protein coupled receptor GPCR41 ADCK5 8q24.3 aarF domain containing kinase 5 CPSF1 8q24-q23 cleavage and polyadenylation specific factor 1, 160kDa SLC39A4 8q24.3 solute carrier family 39 (zinc transporter), member 4 VPS28 8q24.3 vacuolar protein sorting 28 (yeast) NFKBIL2 8q24.3 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2 MGC13010 8q24.3 hypothetical protein MGC13010 KIFC2 8q24.3 likely ortholog of mouse kinesin family member C2 FOXH1 8q24.3 forkhead box H1 PPP1R16A 8q24.3 protein phosphatase 1, regulatory (inhibitor) subunit 16A GPT 8q24.3 glutamic-pyruvate transaminase (alanine aminotransferase) LOC113655 8q24.3 hypothetical protein BC011982 RECQL4 8q24.3 RecQ protein-like 4 KIAA0014 8q24.3 RecQ protein-like 4 LOC389698 8 LOC389698 KIAA1688 8q24.3 KIAA1688 protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1112 - 233 - 2001 11134028
10 - 994 - 221 - 2001 11134028
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Cardiovascularheart    
Endocrinepancreas    
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal domain of VPS28 has a hydrophobic binding site on its surface that is conformationally dynamic
  • a C-terminal domain involved in interactions with other ESCRT components
  • HOMOLOGY
    interspecies ortholog to yeast S.cerevisiae Vps28p classE
    Homologene
    FAMILY ESCRT-I complex (endosomal complexes required for transport)
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • removal of endosomal protein-ubiquitin conjugates
  • functions as a molecular switch for the GEF activity of SOS1, directing this activity toward RAC1
  • involved in sorting ubiquitinated proteins to multivesicular bodies as well as in mediating budding of retroviruses
  • functions likely as a negative modulator of the SOS1–RAS signaling events initiated by peptide growth factors including EGF
  • VPS28, VPS24, and VPS25 are required for dendrite stabilization in mature neurons
  • P
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • AP1G2 specifically interacts with the ESCRT subunits VPS28 and CHMP2A
  • UBAP1, a subunit of human ESCRT-I, coassembles in a stable 1:1:1:1 complex with TSG101, VPS28, and VPS37A
  • physically associates with SOS1 and thereby inhibits the GEF activity of SOS1 on RAS, which prevents the epidermal growth factor (EGF)-induced activation of the RAS–ERK1/2 pathway
  • blocks cyclin D1 expression, as well as DNA synthesis, induced by EGF-stimulated Erk1/2 pathway
  • )
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS