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FLASH GENE
Symbol VNN2 contributors: SGE/npt - updated : 23-04-2009
HGNC name vanin 2
HGNC id 12706
Location 6q23.2      Physical location : 133.065.009 - 133.084.598
Synonym name
  • pantetheinase
  • glycosylphosphatidyl inositol-anchored protein GPI-80
  • protein FOAP-4
  • Synonym symbol(s) FOAP-4, GPI-80
    EC.number 3.5.1.-, 3.56.1.-
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem, component of a cluster
    text
  • lies in close proximity to VNN1 and VNN3
  • in the same transcriptional orientation
  • STRUCTURE 19.59 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    ARG1 6q22.3-q23.1 arginase, liver CRSP3 6q22.33-q24.1 cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa ENPP3 6q22 ectonucleotide pyrophosphatase/phosphodiesterase 3 OR2A4 6q33-q35 olfactory receptor, family 2, subfamily A, member 4 ENPP1 6q22-q23 ectonucleotide pyrophosphatase/phosphodiesterase 1 CTGF 6q23.1 connective tissue growth factor MOXD1 6q22-q23 monooxygenase, DBH-like 1 STX7 6q22.3-q24 syntaxin 7 TAR3 6q23.1 trace amine receptor 3 GPR102 6q23.2 G protein-coupled receptor 102 TA4 6q23.1 trace amine receptor 4 PNR 6q23 putative neurotransmitter receptor GPR57 6q23-q24 G protein-coupled receptor 57 GPR58 6q23-q24 G protein-coupled receptor 58 TAR1 6q23.1 trace amine receptor 1 VNN1 6q23-q24 vanin 1 VNN3 6q23-q24 vanin 3 VNN2 6q23-q24 vanin 2 C6orf192 6q22.3-q23.3 chromosome 6 open reading frame 192 RPS12 6q23.1 ribosomal protein S12 LOC134870 6q23.1 similar to 60S ribosomal protein L23a EYA4 6q23 eyes absent homolog 4 (Drosophila) MGC34034 6q23.2 hypothetical protein MGC34034 TCF21 6q23-q24 transcription factor 21 FLJ35700 6q23.2 hypothetical protein FLJ35700
    regionally located may be four alternative spliced variants (Nitto 2008)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 splicing 2034 58.5 520 - Martin
    a different N terminus containing a leader peptide
    8 splicing 1976 52.7 467 - Martin
  • having a different 5'end exon
  • translation starting at a downstream MET
  • lacking a leader peptide
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
     thymus    
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticneutrophil
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • putative GPI anchored cell surface molecule, with a GPI cleavage site
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Vnn1,Vnn2
    homolog to Drosophila Cg3599
    homolog to rattus Vnn3 (61.5pc)
    homolog to murine Vnn3 (61.7pc)
    intraspecies homolog to Biotinidase
    Homologene
    FAMILY
  • carbon-nitrogen hydrolase family
  • vanin subfamily
  • CATEGORY adhesion , enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text membrane-associated protein by a GPI-anchor
    basic FUNCTION
  • involved in lymphocyte migration and cell adhesion
  • pantetheinase activity playing a role in oxidative-stress response
  • playing a role in transendothelial migration of neutrophils
  • involved in the thymus homing of bone marrow cells
  • ectoenzyme
  • modulator of beta2 integrin functions (Nitto 2008)
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism vitamin
    signaling
    vitamin B5 metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associated with CD18 (Nitto 2008)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS