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FLASH GENE
Symbol VNN1 contributors: - updated : 05-05-2006
HGNC name vanin 1
HGNC id 12705
Location 6q23-q24      Physical location : 133.001.997 - 133.035.194
Synonym name vascular non-inflammatory molecule 1
Synonym symbol(s) TIFF66
EC.number 3.5.1.-, 3.56.1.-
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem, component of a cluster
text
  • lies in close proximity to VNN3 and VNN2
  • in the same transcriptional orientation
  • STRUCTURE 32.00 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    ARG1 6q22.3-q23.1 arginase, liver CRSP3 6q22.33-q24.1 cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa ENPP3 6q22 ectonucleotide pyrophosphatase/phosphodiesterase 3 OR2A4 6q33-q35 olfactory receptor, family 2, subfamily A, member 4 ENPP1 6q22-q23 ectonucleotide pyrophosphatase/phosphodiesterase 1 CTGF 6q23.1 connective tissue growth factor MOXD1 6q22-q23 monooxygenase, DBH-like 1 STX7 6q22.3-q24 syntaxin 7 TAR3 6q23.1 trace amine receptor 3 GPR102 6q23.2 G protein-coupled receptor 102 TA4 6q23.1 trace amine receptor 4 PNR 6q23 putative neurotransmitter receptor GPR57 6q23-q24 G protein-coupled receptor 57 GPR58 6q23-q24 G protein-coupled receptor 58 TAR1 6q23.1 trace amine receptor 1 VNN1 6q23-q24 vanin 1 VNN3 6q23-q24 vanin 3 VNN2 6q23-q24 vanin 2 C6orf192 6q22.3-q23.3 chromosome 6 open reading frame 192 RPS12 6q23.1 ribosomal protein S12 LOC134870 6q23.1 similar to 60S ribosomal protein L23a EYA4 6q23 eyes absent homolog 4 (Drosophila) MGC34034 6q23.2 hypothetical protein MGC34034 TCF21 6q23-q24 transcription factor 21 FLJ35700 6q23.2 hypothetical protein FLJ35700
    RNA
    TRANSCRIPTS type messenger
    text minor transcripts were also detected (Galland)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
     thymus    
    Digestiveintestinesmall intestine   
     liver    
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    putative GPI anchored cell surface molecule,containing a leader peptide and a putative GPI-cleavage motif
    conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Vnn1
    ortholog to Drosophila Vanin-like
    intraspecies homolog to biotinidase
    Homologene
    FAMILY
  • carbon-nitrogen hydrolase family
  • vanin subfamily
  • CATEGORY adhesion , enzyme , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text
  • secreted
  • membrane-associated protein by a GPI-anchor
  • basic FUNCTION
  • involved in lymphocyte migration in cell adhesion and in the colonization of the thymus by hematopoietic precursor cells
  • regulation of Sertoli cells
  • pantetheinase activity playing a role in oxidative-stress response
  • hydrolyzing specifically one of carboamide linkages in D-pantetheinase thus recycling pantothenic acid
  • ectoenzyme
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS