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FLASH GENE
Symbol VKORC1L1 contributors: mct - updated : 06-05-2014
HGNC name vitamin K epoxide reductase complex, subunit 1-like 1
HGNC id 21492
Location 7q11.21      Physical location : 65.338.256 - 65.419.799
DNA
TYPE functioning gene
STRUCTURE 86.29 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 5913 - 176 - 2013 23928358
2 - 5803 - 177 - 2013 23928358
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain     Rattus norvegicus
Reproductivemale systemtestis    Rattus norvegicus
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four-transmembrane domain protein (
  • with both its termini located in the cytoplasm
  • HOMOLOGY
    intraspecies paralog to VKORC1
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • localized exclusively to membranes of the endoplasmic reticulum
  • basic FUNCTION
  • proposed to be responsible for driving vitamin K-mediated intracellular antioxidation pathways critical to cell survival by generating vit KH2, a potent biological antioxidant
  • responsible for driving vitamin K-mediated intracellular antioxidation pathways critical to cell survival
  • is able to catalyze this reaction with a catalytic efficiency 2-fold higher than that of human VKORC1, suggesting an important role of VKORC1L1
  • able to support vitamin K 2,3-epoxide reductase (VKOR) activity and may constitute an alternative pathway to VKORC1 in some tissues
  • not inhibited by vitamin K antagonists (VKAs) and catalyzes VKOR activity in extrahepatic tissues
  • reduces vitamin K epoxide to support vitamin K-dependent carboxylation as efficiently as does VKORC1
  • VKORC1L1 and VKORC1 might potentially have different physiological functions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS