basic FUNCTION
| proposed to be responsible for driving vitamin K-mediated intracellular antioxidation pathways critical to cell survival by generating vit KH2, a potent biological antioxidant |
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responsible for driving vitamin K-mediated intracellular antioxidation pathways critical to cell survival |
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is able to catalyze this reaction with a catalytic efficiency 2-fold higher than that of human VKORC1, suggesting an important role of VKORC1L1 |
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able to support vitamin K 2,3-epoxide reductase (VKOR) activity and may constitute an alternative pathway to VKORC1 in some tissues |
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not inhibited by vitamin K antagonists (VKAs) and catalyzes VKOR activity in extrahepatic tissues |
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reduces vitamin K epoxide to support vitamin K-dependent carboxylation as efficiently as does VKORC1 |
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VKORC1L1 and VKORC1 might potentially have different physiological functions |