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FLASH GENE
Symbol VIPR1 contributors: mct - updated : 23-09-2011
HGNC name vasoactive intestinal peptide receptor 1
HGNC id 12694
Location 3p22.1      Physical location : 42.544.103 - 42.579.065
Synonym name
  • pituitary adenylate cyclase-activating polypeptide receptor, type II
  • PACAP type II receptor
    • Synonym symbol(s) RDC1, HVR1, VPAC1, PACAPR2, FLJ41949, HVR1, II, PACAP-R-2, VIRG
    DNA
    TYPE functioning gene
    STRUCTURE 34.96 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2834 - 495 not binding 12S1-VIP 2006 16888167
    67 divergent N terminal AA
    13 - 2771 - 457 - 2006 16888167
    HIVR8
    - - 2754 - 457 - 2006 16934434
  • truncated isoform lacking the region in the third intracellumlar loop, the fourth extra-cellular loop and TM6-7
  • having a severe inability to activate adenylate-cyclase and produce cAMP
    		•
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivegallbladder    
     intestinelarge intestinecolon highly
    Nervousbrainlimbic systemhippocampus predominantly Homo sapiens
     brain   predominantly Homo sapiens
    Reproductivefemale systembreastmammary gland highly
     male systemprostate  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral  predominantly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM)
  • N-terminal ectodomain with a major VIP-binding site
    • HOMOLOGY
    Homologene
    FAMILY
  • secretin receptor superfamily, G protein coupled
    • CATEGORY regulatory , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    text
  • localized in cell nuclear fraction
    • basic FUNCTION
  • involved in the regulation of important biological functions
  • dual role for VIPR1 and VIPR2 receptors in mediating the antiproliferative effects of VIP with VIPR2 appearing to play a more dominant role
  • VIP and its receptors (VIPR1, VIPR2) are involved in proliferation, survival, and differentiation in human breast cancer cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • coupling with Gs alpha protein and activating adenylate cyclase
  • receptor for VIP
  • binding to HIV-1 (facilitating its productive infection)
  • interaction with VIP and VIPR2 (expands the pool of symmetrically dividing postnatal dentate gyrus precursors via VIPR2 receptors or directs them toward a neuronal fate via VIPR1 receptors)
    • cell & other
    REGULATION
    Other regulated by short promoter,during enterocytic differentiation of the cancer cell line CaCa-2CL20
    activity of this receptor is mediated by G proteins which
    activate adenylyl cyclase
    regulated by NR1H4 agonists in the gallbladder epithelium
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer as compared to non-tumor tissue (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS