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FLASH GENE
Symbol VIPAS39 contributors: mct - updated : 09-07-2015
HGNC name VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
HGNC id 20347
Corresponding disease
ARCS2 arthrogryposis, renal dysfunction, and cholestasis 2
Location 14q24.3      Physical location : -
Synonym name
  • hypothetical protein LOC63894
  • chromosome 14 open reading frame 133
  • VPS33B-interacting protein involved in polarity and apical protein restriction
  • SPE-39 protein
  • VPS33B interacting protein, apical-basolateral polarity regulator
  • Synonym symbol(s) FLJ12707, VPS16B, SPE-39, SPE39, C14orf133, VIPAR
    DNA
    TYPE functioning gene
    STRUCTURE 30.89 kb     21 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 2810 - 493 - 2009 19109425
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    interspecies ortholog to C. elegans spe-39
    Homologene
    FAMILY
  • SPE-39 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • previously unrecognized regulator of lysosomal delivery
  • required for trafficking from early stages of the endocytic pathway (RAB11 and RAB5 compartments) toward lysosomes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • HOPS (fusion and vacuole protein sorting) complexes
  • VIPAR forms a functional complex with VPS33B that interacts with RAB11A
  • VPS33B-VIPAR complex has diverse functions in the pathways regulating apical-basolateral polarity in the liver and kidney
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • VPS33B-interacting protein (VPS33B and VIPAS39 function as part of a complex that interacts with an active form of RAB11A involved in apical membrane protein sorting)
  • VIPAS39, with its partner proteins, regulate sorting of PLOD3 into newly identified post-Golgi collagen IV carriers and VIPAS39-dependent sorting is essential for modification of lysines in multiple collagen types
  • also interacts with VPS33 homologues and both coimmunoprecipitates and cosediments with other HOPS subunits
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ARCS2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS