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FLASH GENE
Symbol VGLL4 contributors: mct - updated : 06-01-2021
HGNC name vestigial like 4 (Drosophila)
HGNC id 28966
Location 3p25.3      Physical location : 11.597.543 - 11.762.220
Synonym name
  • transcription cofactor vestigial-like protein 4
    • Synonym symbol(s) VGL-4, KIAA0121
    DNA
    TYPE functioning gene
    STRUCTURE 164.68 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 3725 - 290 - 2011 21839727
    5 - 3783 - 296 - 2011 21839727
    4 - 3182 - 210 - 2011 21839727
    4 - 3425 - 206 - 2011 21839727
    7 - 3652 - 295 - 2011 21839727
    5 - 3562 - 231 - 2011 21839727
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two TDU motifs , two tandem TDU motifs, suggesting that VGLL4 has distinct molecular functions among this family
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    text
  • expressed predominantly in the nucleus
    • basic FUNCTION
  • modulates the activity of TEAD1 factors and counteracts alpha1-adrenergic activation of gene expression in cardiac myocytes)
  • functions as a transcription cofactor in cardiac myocytes
  • may play a role in the apoptotic pathways by regulating translocation of BIRC2, BIRC3 and XIAP between different cell compartments
  • could antagonize the anti-apoptotic activity of BIRC2, BIRC3 and XIAP by sequestering IAPs in nucleus
  • VGLL4 is a novel regulator of survival in human embryonic stem cells
  • is a novel tumor suppressor for lung cancer through negatively regulating the YAP1-TEAD complex formation and thus the Hippo pathway
  • acetylation-mediated, VGLL4-dependent switch that regulates TEAD stability and YAP1-TEAD activity
  • VGLL4 is a transcriptional repressor that interacts with transcription factors TEADs and inhibits YAP1-induced overgrowth and tumorigenesis
  • USP11 controls VGLL4 protein stability by promoting its deubiquitination
  • VGLL4 is a candidate tumor suppressor gene which acts by selectively antagonizing YAP1-dependent tumor growth
  • VGLL4 is found to play an important role in several signal pathways, mainly acts as a tumor suppressor interacting with TEADs, and can also suppress epithelial-mesenchymal transition (EMT) and contribute to apoptosis signaling pathway
  • VGLL4 is important for valve development
  • VGLL4 plays an important role in regulating osteoblast differentiation and bone development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • TEAD4-VGLL4-CTBP2 ternary complex dynamically existed at the early stage of adipogenesis
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BIRC2, BIRC3 and XIAP binding protein
  • negatively regulates the TEAD1-YAP1 transcriptional complex and exerts its growth inhibitory control through its evolutionary conserved TDU2 domain at its C-terminus
  • functions as a transcriptional co-repressor in the Hippo-Yes-associated protein (YAP1) pathway
  • VGLL4 acted as an adaptor protein that enhanced the interaction between TEAD4 and CTBP2
  • VGLL4 is an important regulator of CD274 expression, suggesting a central role of VGLL4 and YAP1 in the regulation of tumor immunity
    • cell & other
    REGULATION
    Phosphorylated by CDK1 (phosphorylated CDK1 during antimitotic drug-induced mitotic arrest and also in normal mitosis)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    was very important in the progression of esophageal squamous cell carcinoma (ESCC)
    tumoral     --over  
    reduces breast cancer cell proliferation, migration, intravasation/extravasation potential, favors cell death, and suppresses tumor growth
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveoesophagus
    restoring the function of VGLL4 might be a promising therapeutic strategy for ESCC
    cancerreproductivebreast
    may be a promising therapeutic target in breast cancer
    ANIMAL & CELL MODELS