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Symbol VGLL4 contributors: mct - updated : 15-09-2012
HGNC name vestigial like 4 (Drosophila)
HGNC id 28966
Location 3p25.3      Physical location : 11.597.543 - 11.762.220
Synonym name
  • transcription cofactor vestigial-like protein 4
  • Synonym symbol(s) VGL-4
    DNA
    TYPE functioning gene
    STRUCTURE 164.68 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 3725 - 290 - 2011 21839727
    5 - 3783 - 296 - 2011 21839727
    4 - 3182 - 210 - 2011 21839727
    4 - 3425 - 206 - 2011 21839727
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    text
  • expressed predominantly in the nucleus
  • basic FUNCTION
  • modulates the activity of TEAD1 factors and counteracts alpha1-adrenergic activation of gene expression in cardiac myocytes)
  • functions as a transcription cofactor in cardiac myocytes
  • may play a role in the apoptotic pathways by regulating translocation of BIRC2, BIRC3 and XIAP between different cell compartments
  • could antagonize the anti-apoptotic activity of BIRC2, BIRC3 and XIAP by sequestering IAPs in nucleus
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BIRC2, BIRC3 and XIAP binding protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS