SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,lumen
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytosolic,vesicle
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text
| stored in and released from secretory vesicles (Chakraborty 2006) |
basic FUNCTION
| play roles in the regulation of body weight, feeding, and energy expenditure (Chakraborty 2006) |
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VGF may act downstream of BDNF and exert its effects as an antidepressant-like agent by enhancing neurogenesis in the hippocampus |
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VGF and/or VGF-derived peptides modulate sympathetic outflow pathways to regulate fat storage and energy expenditure |
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role of VGF in mood disorders |
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multiplicity of roles for VGF peptides, including endocrine functions, local intercellular communication, as well as the possible mediation of intracellular mechanisms |
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plays a role in energy homeostasis and promotes growth and survival |
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age-dependent increase in VGF-expression could serve as mechanism that counterregulates the decrease in functionality of T lymphocytes |
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contributes to survival and function of peripheral T cells |
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plays an important role in the maintenance of organismal energy balance and in the mediation of hippocampal synaptic activity |
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hypothalamic VGF responds to environmental demands and plays an important role in energy balance and glycemic control likely acting in the melanocortin pathway downstream of BDNF |
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promotes hippocampal neurogenesis, as well as synaptic activity |
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enhances dendritic maturation and these effects can be altered by common mutations in the VGF gene |
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is a neuropeptide which is expressed in neuronal cells and endocrine cells |