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FLASH GENE
Symbol VENTX contributors: mct - updated : 14-08-2012
HGNC name VENT homeobox homolog (Xenopus laevis)
HGNC id 13639
Location 10q26.3      Physical location : 135.051.407 - 135.055.433
Synonym name
  • VENT-like homeobox 2
  • hemopoietic progenitor homeobox protein VENTX2
    • Synonym symbol(s) HPX42B, VENTX2, MGC119911, MGC119910, NA88A
    DNA
    TYPE functioning gene
    STRUCTURE 4.03 kb     3 Exon(s)
    regulatory sequence cytosine-phosphate-guanine/HTF
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2428 28 258 - 2010 20833819
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticplasma  predominantly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmature hematopoietic Homo sapiens
    Blood/Hematopoieticmyelocyte Homo sapiens
    cell lineage
    cell lines erythroleukemic cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal proline-serine-threonine-rich domain
  • homeobox domain
  • C terminal proline-rich domain
    • HOMOLOGY
    interspecies homolog to xenopus xvent2b
    Homologene
    FAMILY
  • VENT homeoprotein family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION intracellular,nucleus
    basic FUNCTION
  • might act as a potential tumor suppressor by controlling LEF1-mediated transcription
  • LEF1-associated inhibitor of canonical Wnt/beta-catenin signaling and a negative regulator of cell proliferation
  • role for VENTX in normal and malignant myelopoiesis
  • unique regulatory factor of normal and leukemic postnatal hematopoietic cells
  • having ability to promote a myeloid fate on early hematopoietic progenitor cells while suppressing erythroid differentiation
  • more involved in myeloid differentiation pathways than in stem cell or lymphoid cell development
  • is a novel regulator of human Hematopoietic Stem/Multipotent Progenitor Cells expansion
  • anti-proliferation and pro-differentiation factor in human hematopoietic cells
  • regulates the expression of several cell cycle regulators and Wnt downstream genes implicated in HSC/MPP proliferation and differentiation
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • inhibitor of the oncogenic Wnt and as an activator of the TP53/CDKN1A and CDKN2A/RB1 tumor suppressor pathways
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    aberrant expression of VENTX in normal CD34+ progenitor cells perturbs normal hematopoietic development, promoting generation of myeloid cells and impairing generation of lymphoid cells
    tumoral     --other  
    aberrantly expressed in malignant myeloid cells with particularly high expression in AML cases with t(8;21) or normal karyotype
    tumoral     --low  
    in chronic lymphocytic leukemia
    tumoral     --other  
    altered expression associated with corresponding changes of LEF1 target oncogenes such as CCND1, suggesting a potential role of VENTX in the clinical behavior of hematopoietic malignancies
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS