basic FUNCTION
| vascular endothelial growth factor, key regulator of blood vessel growth, and protecting endothelial cells from apoptosis |
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an essential coordinator of chondrocyte death, chondroclast function, extracellular matrix remodeling, angiogenesis and bone formation in the growth plate |
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angioneurin, involved in vasculogenesis and acting as a neurotrophic factor for motor neurons (protection against ischemic death) |
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a modifier of cardiovascular birth defects in the del22q11 syndrome  |
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modulating erythropoiesis through regulation of adult hepatic erythropoietin synthesis and negative regulator of hepatic EPO synthesis and erythropoiesis |
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acting in concert with TGF-beta1 to induce endothelial cell apoptosis |
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having a functional role for recruitment of osteoprogenitor cells in the course of endochondral bone formation or remodeling |
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controls angiogenic sprouting in the early postnatal retina by guiding filopodial extension from specialized endothelial cells situated at the tips of the vascular sprouts |
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role for VEGFA and TNFSF14 in macrophage apoptosis during wound healing, an event critical in the resolution of inflammation  |
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playing a role as an inhibitor of neovascularization on the basis of its capacity to disrupt vascular smooth muscle cellsfunction  |
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essential role for endocardial cushion formation  |
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in primary endothelial cells, hypoxia stimulates VEGFA and FLT1 expression but decreases KDR levels  |
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is the most important IL17A-induced angiogenic factor  |
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predominant Hh-induced proangiogenic factor driving tumor angiogenesis  |
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modulator of NMDAR function in neurons before synapses are formed  |
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important for endothelial cell migration and angiogenesis mediated via complex formation between NRP1 and KDR and increased signaling to focal adhesions  |
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VEGFA and extracellular collagen matrix (FRK/COL10A1) pathways contribute to the development of advanced age-related macular degeneration  |
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plays a key role in controlling neural precursor populations in developing cortex  |
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balance between the pro-leakage effects of VEGFA and anti-leakage effects of the angiopoietins (ANGPT1, ANGPT2), in part, modulates vascular integrity and oxygen delivery  |
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RUNX2, HIF1A, and VEGFA may regulate vascular angiogenesis spatially and temporally in the hypertrophic zone of the growth plate during endochondral bone formation  |
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regulator of vascularization in development and is a key growth factor in tissue repair  |
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essential roles in blood vessel growth  |
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also promotes a wide range of neuronal functions, including neurogenesis, neuronal migration, neuronal survival and axon guidance  |
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mesenchymal stem cells (MSCs)-secreted IL6 and VEGFA may act as paracrine factors to sustain breast cancer cell migration  |
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is involved in angiogenesis and osteogenesis coupled during bone formation  |
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VEGFA pathway could play a predominant role in the cause of atrioventricular septal defects (AVSD) in Down syndrome  |
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myocardially produced VEGFA signals through endocardial KDR to stimulate ventricular endocardial cells to undergo angiogenesis that generates coronary arteries  |
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VEGFA and ANGPT1 regulate endothelial cell (EC) junctions by determining the localization of the RHOA-specific guanine nucleotide exchange factor PLEKHG5  |
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crucial proangiogenic factor, which regulates blood vessel supply under physiologic and pathologic conditions  |
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VEGFA and FGF2 are potent pro-angiogenic factors and play a critical role in cancer development and progression  |