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FLASH GENE
Symbol VDAC3 contributors: mct - updated : 03-12-2019
HGNC name voltage-dependent anion channel 3
HGNC id 12674
Location 8q11.21      Physical location : 42.249.345 - 42.263.413
Synonym name
  • porin 3
  • outer mitochondrial membrane protein porin 3
  • Synonym symbol(s) HD-VDAC3
    DNA
    TYPE functioning gene
    STRUCTURE 14.07 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    regionally located previously mapped to chromosome 12
    RNA
    TRANSCRIPTS type messenger
    text two isoforms,one with the other lacking an inserted MET, 31aa downstream N terminal (PMID: 9804816)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1458 - 283 - 1998 9804816
    11 - 1461 - 284 - 1998 9804816
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinesmall intestine  highly
    Reproductivemale systemtestis  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    ReproductiveLeydig cell
    Reproductivespermatozoa
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Vdac3
    Homologene
    FAMILY
  • eukaryotic mitochondrial porin family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    text
  • located in human spermatozoa, especially in sperm flagella )
  • basic FUNCTION
  • voltage-dependent anion channel 3, allowing diffusion of small hydrophilic molecules
  • with others VDACs, are dispensable for both mitochondrial permeability transition and BCL2 family member-driven cell death
  • mitochondrial porin, identified in the mitochondrial outer membrane that is able to form hydrophilic pore structures
  • having differing mitochondrial functions in two types of striated muscles
  • pore-forming proteins mainly located in the mitochondrial outer membrane
  • having a limited ability to support the mitochondrial respiration and has no influence in the control of ROS production
  • roles in human sperm motility, capacitation and acrosomal reaction
  • VDAC1, VDAC2, VDAC3 serve as mitochondrial docking sites to recruit PRKN from the cytosol to defective mitochondria
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with cyclophilin D (PPID) and adenine nucleotide translocases (SLC25A4, SLC25A5, ANT3X) at the inner mitochondrial permeability transition pore
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • in Vdac3 deficient mice the defect is restricted to the heart and only to complex IV
  • male mice with Vdac3-deficiency exhibits markedly reduced sperm motility and infertile, but their testicular structure and numbers of sperm are normal