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FLASH GENE
Symbol VDAC2 contributors: mct - updated : 25-10-2010
HGNC name voltage-dependent anion channel 2
HGNC id 12672
Location 10q22.2      Physical location : 76.969.911 - 76.991.204
Synonym name
  • porin 2
  • outer mitochondrial membrane protein porin 2
  • voltage-dependent anion-selective channel protein 2
  • Synonym symbol(s) FLJ23841, VDAC-2, POR
    DNA
    TYPE functioning gene
    STRUCTURE 20.64 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    SEC24C 10q22.3 SEC24 related gene family, member C (S. cerevisiae) FUT11 10q22.3 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) LOC118487 10q22.3 similar to RIKEN cDNA 1110001O19 LOC196752 10q22.3 similar to CG32542-PA KIAA0913 10q22.3 KIAA0913 protein NDST2 10q22 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 CAMK2G 10q22.3 calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma PLAU 10q23.3-q24.3 plasminogen activator, urokinase VCL 10q22.1-q23 vinculin AP3M1 10q22.3 adaptor-related protein complex 3, mu 1 subunit ADK 10q22.3 adenosine kinase MRPL35P3 10q22.2 adenosine kinase LOC389979 10 similar to hypothetical protein DKFZp586O0120.1 - human (fragment) MYST4 10q22.2 MYST histone acetyltransferase (monocytic leukemia) 4 DUPD1 10q22.3 dual specificity phosphatase and pro isomerase domain containing 1 DUSP13 10q22.3 dual specificity phosphatase 13 SAMD8 10q22.3 sterile alpha motif domain containing 8 VDAC2 10q22 voltage-dependent anion channel 2 FLJ23841 10q22.3 hypothetical protein FLJ23841 LOC387687 10 LOC387687 SPA17P1 10q22.3 sperm autoantigenic protein 17 pseudogene 1 ZNF503 10q22.3 zinc finger protein 503 LOC283065 10q22.3 hypothetical gene supported by BC017426 LOC387688 10 LOC387688 CDA017
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1785 31 294 - 2008 18278581
    - - 1447 - 294 -
    - - 1963 - 309 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Reproductivemale systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Muscularstriatumskeletal highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatid
    Reproductivespermatocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two cysteines in the N-terminus but they are placed differently than in VDAC3 N-terminus
  • a longer, unstructured 11 AA long extension containing one N-terminal cysteine
  • HOMOLOGY
    Homologene
    FAMILY
  • eukaryotic mitochondrial porin family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    text
  • located in human spermatozoa, especially in sperm flagella
  • found in plasma membrane and/or acrosomal membrane of acrosomal region
  • basic FUNCTION
  • voltage-dependent anion channel 2, allowing diffusion of small hydrophilic molecules
  • with others VDACs, are dispensable for both mitochondrial permeability transition and BCL2 family member-driven cell death
  • mitochondrial porin, identified in the mitochondrial outer membrane that is able to form hydrophilic pore structures
  • pore-forming proteins mainly located in the mitochondrial outer membrane
  • acts as a crucial component in mitochondrial apoptosis by allowing the mitochondrial recruitment of BAK1, thereby controlling truncated BID-induced outer mitochondrial membrane permeabilization and cell death
  • roles in human sperm motility, capacitation and acrosomal reaction
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with cyclophilin D (PPID) and adenine nucleotide translocases (SLC25A4, SLC25A5, ANT3X) at the inner mitochondrial permeability transition pore
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the hydrophobic tail of BAK1 to sequester it in an inactive state in the mitochondrial outer membrane, thereby raising the stimulation threshold necessary for permeabilization of the mitochondrial outer membrane and cell death
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS