Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol VDAC2 contributors: mct - updated : 28-11-2019
HGNC name voltage-dependent anion channel 2
HGNC id 12672
Location 10q22.2      Physical location : 76.969.911 - 76.991.204
Synonym name
  • porin 2
  • outer mitochondrial membrane protein porin 2
  • voltage-dependent anion-selective channel protein 2
  • epididymis secretory sperm binding protein
  • Synonym symbol(s) FLJ23841, VDAC-2, POR
    DNA
    TYPE functioning gene
    STRUCTURE 21.29 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 1785 31 294 - 2019 31015432
    10 - 1447 - 294 - 2019 31015432
    12 - 2003 - 309 - 2019 31015432
    12 - 1929 - 255 - 2019 31015432
    12 - 1871 - 255 - 2019 31015432
    12 - 1707 - 255 - 2019 31015432
    11 - 1603 - 294 - 2019 31015432
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Nervousbrain   predominantly Homo sapiens
    Reproductivemale systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Muscularstriatumskeletal highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatid
    Reproductivespermatocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two cysteines in the N-terminus but they are placed differently than in VDAC3 N-terminus
  • a longer, unstructured 11 AA long extension containing one N-terminal cysteine
  • HOMOLOGY
    Homologene
    FAMILY
  • eukaryotic mitochondrial porin family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    text
  • located in human spermatozoa, especially in sperm flagella
  • found in plasma membrane and/or acrosomal membrane of acrosomal region
  • VDAC2 is the most predominant isoform seen in brain mitochondria
  • basic FUNCTION
  • voltage-dependent anion channel 2, allowing diffusion of small hydrophilic molecules
  • with others VDACs, are dispensable for both mitochondrial permeability transition and BCL2 family member-driven cell death
  • mitochondrial porin, identified in the mitochondrial outer membrane that is able to form hydrophilic pore structures
  • pore-forming proteins mainly located in the mitochondrial outer membrane
  • acts as a crucial component in mitochondrial apoptosis by allowing the mitochondrial recruitment of BAK1, thereby controlling truncated BID-induced outer mitochondrial membrane permeabilization and cell death
  • roles in human sperm motility, capacitation and acrosomal reaction
  • VDAC2 may facilitate mitochondrial Ca(2+) uptake and restrict Ca(2+) spark expansion without regulating activations of sparks under resting conditions, thereby providing evidence on the functional role of VDAC2 in cardiac local Ca(2+) signaling
  • VDAC1, VDAC2, VDAC3 serve as mitochondrial docking sites to recruit PRKN from the cytosol to defective mitochondria
  • is not only crucial for cell survival but is also implicated in Alzheimer disease
  • critical modulatory role for VDAC2-dependent mitochondrial Ca(2+) uptake in the regulation of cardiac rhythmicity
  • VDAC1, VDAC2, and VDAC3, are pore-forming proteins that control metabolite flux between mitochondria and cytoplasm
  • functions primarily as the crucial anti-apoptotic protein in the outer mitochondrial membrane, and additionally as a gated bidirectional metabolite transporter
  • VDAC1, VDAC2, VDAC3 are paralogs with a similar pore-function and slightly different, but important, ancillary biological functions
  • role of VDAC2 as direct effector of ceramide-mediated cell death, providing a molecular framework for how ceramides exert their anti-neoplastic activity
  • general role for VDAC1, role as an actor of apoptosis for VDAC2, and the involvement in sex determination and development of VDAC3
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with cyclophilin D (PPID) and adenine nucleotide translocases (SLC25A4, SLC25A5, ANT3X) at the inner mitochondrial permeability transition pore
  • INTERACTION
    DNA
    RNA
    small molecule
  • VDAC3 exhibits the highest calcium permeability, followed by VDAC2 and VDAC1, thus pointing to isoform-dependent physiological function
  • protein
  • control of ALDOA and VDAC2 levels by iron status of the cell
  • interacts with the hydrophobic tail of BAK1 to sequester it in an inactive state in the mitochondrial outer membrane, thereby raising the stimulation threshold necessary for permeabilization of the mitochondrial outer membrane and cell death
  • BAX localizes to the mitochondrial outer membrane via alternate mechanisms, either constitutively via an interaction with VDAC2 or after activation via interaction with BCL2 family proteins
  • bifunctional role of VDAC2 to target BAX specifically to the mitochondria and ensure BAX inhibition by retrotranslocation into the cytosol
  • VDAC1 and VDAC2 are mitochondrial ceramide binding proteins
  • MTD domain of PMAIP1 causes mitochondrial damage by opening mitochondrial permeability transition pore (mPTP) through VDACs, especially VDAC2, during necrotic cell death
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource MITOP database
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    abnormal methylation of VDAC2 promoter may be a potential cause to idiopathic asthenospermia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS