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Symbol VDAC1 contributors: mct/shn - updated : 02-02-2016
HGNC name voltage-dependent anion channel 1
HGNC id 12669
Corresponding disease
MTENC4 mitochondrial encephalomyopathy, fatal in childhood 4
Location 5q31.1      Physical location : 133.307.606 - 133.340.433
Synonym name
  • outer mitochondrial membrane protein porin 1
  • plasmalemmal porin
  • porin 31HL
  • porin 31HM
  • voltage-dependent anion-selective channel protein
  • Synonym symbol(s) PORIN, PORIN-31-HL, hVDAC1, MGC111064
    TYPE functioning gene
    STRUCTURE 32.83 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site
    text structure
  • a sterol repressor element
  • a SRY
  • a NRF2 binding sites
  • MAPPING cloned Y linked N status confirmed
    Map cen - D5S2117 - D5S2053 - VDAC1 - D5S808 - D5S458 - qter
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1993 30.8 283 - -
    9 splicing 2074
    9 splicing 2071
    Type ubiquitous
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   predominantly
    Digestiveesophagus   highly
     intestinelarge intestinecolon moderately
     liver   moderately
    Lymphoid/Immunethymus   moderately
    Nervousbrain   moderately
    Reproductivefemale systembreastmammary gland moderately
     male systemtestis  highly Homo sapiens
    Skin/Tegumentskin   highly
    Urinarybladder   moderately
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  moderately
    SystemCellPubmedSpeciesStageRna symbol
    ReproductiveSertoli cell
    Reproductivespermatozoa Homo sapiensAdult
    cell lineage
    cell lines
    fluid/secretion lymph
    at STAGE
  • N-terminal domain indicated to be a main effector in the apoptotic events depending on VDAC1
  • conjugated PhosphoP , Other
    interspecies ortholog to Vdac, Rattus norvegicus
    ortholog to Vdac1, Mus musculus
    ortholog to VDAC1, Pan troglodytes
    ortholog to vdac1, Danio rerio
  • eukaryotic mitochondrial porin family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     intracellular
    text located in human spermatozoa, especially in sperm flagella
    basic FUNCTION
  • allowing diffusion of small hydrophilic molecules
  • acting as an apoptogenic cytochrome c release channel
  • mitochondrial porin, main pathway for metabolites across the mitochondrial outer membrane and that may serve as binding sites for kinases, including hexokinase
  • acting as a NADH-ferricyanide reductase
  • involved in the maintenance of cellular redox homeostasis
  • playing a vital role in modulating ES-induced endothelial cell apoptosis
  • involved in cell volume regulation
  • may participate in the formation of the permeability transition pore complex responsible for the release of mitochondrial products that triggers apoptosis
  • with others VDACs, are dispensable for both mitochondrial permeability transition and BCL2 family member-driven cell death
  • mitochondrial porin, identified in the mitochondrial outer membrane that is able to form hydrophilic pore structures
  • pore-forming proteins mainly located in the mitochondrial outer membrane
  • roles in human sperm motility, capacitation and acrosomal reaction
  • E72Q-VDAC1 has a dominant-negative effect and implies that VDAC1 homo-oligomerization, involving intermolecular interactions, might be involved in the apoptotic process
  • most abundant protein in the mitochondrial outer membrane
  • VDAC1, VDAC2, VDAC3 serve as mitochondrial docking sites to recruit PRKN from the cytosol to defective mitochondria
  • VDAC1 and SLC25A4 have central roles in mitochondrial functions such as nucleotides transport and cell death
  • VDAC1 serves distinct functions as outer membrane channel for metabolites and as coupling factor for protein translocation into the inner membrane
  • CELLULAR PROCESS cell life, cell death/apoptosis
    text ion transport
    a component
  • complexing with cyclophilin D (PPID) and adenine nucleotide translocases (SLC25A4, SLC25A5, ANT3X) at the inner mitochondrial permeability transition pore
  • acetylation
  • CPT1A forms hetero-oligomeric complexes with ACSL1 and VDAC1 and is part of an outer membrane fatty acid transfer complex
    small molecule
  • translocase of outer mitochondrial membrane 20 homolog (yeast), TOMM20
  • neisserial porin PorB
  • Mitochondrial creatine kinase, MtCK
  • C-Raf kinase
  • tubulin
  • bcl-2 interacting protein Bim
  • protein kinase Cepsilon, PKCepsilon
  • pro-apoptotic Bax and anti-apoptotic Bcl-X(L)
  • dynein light chain Tctex1 and the heat-shock protein PBP74
  • hexokinases
  • direct interaction between NEK1 and VDAC1 providing a mechanism to explain how NEK1 prevents excessive cell death, as well as the first direct evidence that a specific kinase regulates VDAC1 activity
  • binding HK1 and HK2, in the outer mitochondrial membrane (VDAC1-based peptides interfering with HK-mediated anti-apoptotic activity may potentiate the efficacy of conventional chemotherapeutic agents)
  • a target for Parkin-mediated Lys 27 poly-ubiquitylation and mitophagy
  • strong protein-protein interaction between CPT1A, ACSL1, and VDAC1
  • mediating BCL2L1 protection against apoptosis (BCL2L1 acting as antiapoptotic protein, promoting tumor cell survival via binding to VDAC1)
  • binding of PLAT to VDAC1 induced a decrease in K(m) and an increase in the V(max) for activation of its substrate, plasminogen (Pg)
  • MCU interacts with VDAC1 and mediates VDAC1 overexpression-induced cell death in cerebellar granule neurons (CGNs)
  • VDAC1 interacts with carrier precursors arriving in the intermembrane space and recruits TIMM22 complexes, thus ensuring an efficient transfer of the precursors to the inner membrane translocase
  • VDAC1 and VDAC2 are mitochondrial ceramide binding proteins
  • cell & other
    induced by thiol chelators for the NADH-dependent ferricyanide reduction
    Other target for Parkin-mediated polyubiquitination and mitophagy
    corresponding disease(s) MTENC4
    related resource MITOP database
    Variant & Polymorphism
    Candidate gene
    Therapy target