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FLASH GENE
Symbol VCPIP1 contributors: mct - updated : 19-10-2014
HGNC name valosin containing protein (p97)/p47 complex interacting protein 1
HGNC id 30897
Location 8q13.1      Physical location : 67.542.489 - 67.579.452
Synonym symbol(s) VCIP135, FLJ23132, KIAA1850, DKFZp686G038, DUBA3, FLJ60694
EC.number 3.4.22.-
DNA
TYPE functioning gene
STRUCTURE 36.96 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 8176 - 1222 - 2004 15037600
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  moderately
Lymphoid/Immunethymus   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
one OTU domain
HOMOLOGY
interspecies ortholog to rattus VCIP135
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,endoplasmic reticulum
intracellular,cytoplasm,organelle,Golgi
basic FUNCTION
  • acting as a deubiquitinating enzyme
  • VCIP1 and NSFL1C are shown to function in Golgi
  • and ER assembly
  • necessary for VCP- mediated reassembly of Golgi stacks
  • after mitosis
  • may play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER)
  • mediating dissociation of the ternary complex containing STX5A, NSFL1C and VCP
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • VCP
  • NSFL1C is a VCP-binding protein, that functions in Golgi membrane fusion together with VCP and VCPIP1, another VCP-binding protein
  • the ternary complex containing STX5, NSFL1C and VCP
  • interacting with WAC (WAC is hence thought to function in VCP/p47-mediated Golgi membrane fusion by activating the deubiquitinating function of VCPIP1)
  • STX5 is monoubiquitinated by the ubiquitin ligase HACE1 in early mitosis and deubiquitinated by the deubiquitinase VCPIP1 in late mitosis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS