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FLASH GENE
Symbol VBP1 contributors: npt/ - updated : 18-06-2008
HGNC name von Hippel-Lindau binding protein 1
HGNC id 12662
Location Xq28      Physical location : 154.444.700 - 154.468.096
Synonym name
  • prefoldin 3
  • VHL-binding protein 1
  • Synonym symbol(s) PFD3, PFDN3, VBP-1, HIBBJ46
    DNA
    TYPE functioning gene
    STRUCTURE 23.55 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    FAM3A Xq28 family with sequence similarity 3, member A G6PD Xq28 glucose-6-phosphate dehydrogenase IKBKG Xq28 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma SPCX Xq28 SPCX LAGE2A  cancer/testis antigen 1-A CTAG1 Xq28 cancer/testis antigen 1 LOC340600 Xq28 cyclic-AMP-dependent transcription factor ATF-4 pseudogene deltaNEMO Xq28 deltaNEMO CTAG2 Xq28 cancer/testis antigen 2 LOC392561 X similar to olfactory receptor MOR255-2 GAB3 Xq28 GRB2-associated binding protein 3 DKC1 Xq28 dyskeratosis congenita 1, dyskerin MPP1 Xq28 membrane protein, palmitoylated 1, 55kDa LOC158957 Xq28 hypothetical LOC158957 F8 Xq28 coagulation factor VIII, procoagulant component (hemophilia A) HCBP6 Xq28 hepatitis C virus core-binding protein 6 MTCP1 Xq28 mature T-cell proliferation 1 C6.1A Xq28 c6.1A VBP1 Xq28 von Hippel-Lindau binding protein 1 RAB39B Xq28 RAB39B, member RAS oncogene family CLIC2 Xq28 chloride intracellular channel 2 PHF10P1 Xq28 PHD finger protein 10 pseudogene 1 F8A Xq28 coagulation factor VIII-associated (intronic transcript) H2AFB Xq28 H2A histone family, member B TMLHE Xq28 trimethyllysine hydroxylase, epsilon
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1643 22.5 197 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a consensus site for tyrosine phosphorylation
  • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to murine Vbp1
    homolog to Drosophila CG6719
    homolog to C.elegans T06G6.9
    Homologene
    FAMILY
  • prefoldin alpha subunit family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text translocated to the nucleus in complex with VHL
    basic FUNCTION
  • playing a role in the transport of the Von Hippel-Lindau protein from the perinuclear granules to the nucleus or cytoplasm
  • transtering target proteins to cytosolic chaperonin (C-CPN)
  • promoting folding of nascent polypeptide chain in an environment in which there are many competing pathways for nonnative proteins
  • CELLULAR PROCESS protein, post translation, folding
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with VHL to form an intracellular complex
  • heterohaxamer of two PFD-alpha type and four PFD-beta type subunits
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to cytosolic chaperonin (C-CPN), VHL, nascent polypeptide chain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS