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Symbol VAV3 contributors: mct - updated : 23-05-2018
HGNC name vav guanine nucleotide exchange factor 3
HGNC id 12659
Location 1p13.3      Physical location : 108.113.781 - 108.507.545
Synonym name
  • vav 3 guanine nucleotide exchange factor
  • vav 3 oncogene
  • DNA
    TYPE functioning gene
    STRUCTURE 393.76 kb     27 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391064 1 hypothetical gene supported by AK001388 LOC126987 1p13.3 similar to tight junction protein 3 (zona occludens 3) PRMT6 1p13.3 similar to tight junction protein 3 (zona occludens 3) NTNG1 1p13.3 netrin G1 LOC360165  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa, pseudogene VAV3 1p22.3-p11 vav 3 oncogene DKFZp586G0123 1p13.3 calcium-binding transporter FLJ32833 1p13.3 hypothetical protein FLJ32833 LOC388657 1 similar to calcium-binding transporter LOC343141 1p13.3 similar to calcium-binding transporter LOC388658 1 similar to hypothetical protein MGC8902 LOC388659 1 similar to RIKEN cDNA C230093N12 FLJ30525 1p13.3 hypothetical protein FLJ30525 FLJ10330 1p13.3 hypothetical protein FLJ10330 FLJ35838 1p13.3 hypothetical protein FLJ35838 STXBP3 1p21-p13.3 syntaxin binding protein 3 MGC26989 1p13.3 hypothetical protein MGC26989 LGN MCLC 1p13.2 hypothetical protein MGC26989 KIAA0893 1p13.3 hypothetical protein MGC26989 NDUFB3P1 1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa pseudogene 1 AD-020 1p13.3 protein x 013 LOC391065 1 similar to poly(rC) binding protein 1; heterogenous nuclear ribonucleoprotein X; poly(rC)-binding protein 1; alpha-CP1; nucleic acid binding protein sub 2.3; heterogenous nuclear ribonucleoprotein E1 LOC127003 1p13.3 similar to CG5435-PA KIAA1324 1p13.2 maba1
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    27 - 4776 - 847 - 2018 29194596
  • Vav3-alpha
  • 10 - 3115 - 287 - 2018 29194596
  • vav3.1
  • N-terminal truncated lacking its self-regulatory domains
  • its overexpression was associated with poor progression-free and overall survival in ovaraian cancer
    Type widely
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     intestinelarge intestinecolon  
    Nervousbrainhindbraincerebellum highly Homo sapiens
    Visualeyeretina  highly Mus musculusFetal
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    SystemCellPubmedSpeciesStageRna symbol
    NervousPurkinje cell Homo sapiens
    Nervouspyramidal cell Homo sapiens
    cell lineage
    cell lines
    at STAGE
    physiological period pregnancy
    Text placenta
  • a DBL (DH) homology
  • a calponin-homology (CH) domain
  • a pleckstrin homology (PH) and zinc finger domains in the central region
  • an atypical C1 domain, which possesses close structural homology to the typical C1 domains of protein kinase C but which fails to bind the second messenger diacylglycerol or the potent analogs, the phorbol esters
  • a zinc-dependent phorbol-ester and DAG binding domain
  • SH3-SH2-SH3 domains in the C terminal region
    FAMILY VAV family proto-oncogenes
    CATEGORY protooncogene , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • GDP-GTP exchange factor for small Ras-related GTPases like ARHB, ARGH, RAC1
  • Rho family guanine nucleotide exchange factor, playing an essential role for stimulated osteoclast activation and bone density (role in in the actin cytoskeleton organization)
  • GDP-GTP exchange factor that stimulates Rho and Rac GTPases, and acting as an essential factor regulating the homeostasis of the cardiovascular system
  • playing a crucial role in the regulation of the sympathetic nervous system (SNS) and cardiovascular physiology, and reveal a signaling pathway that could be involved in the pathophysiology disease states involving tachycardia and sympathetic hyperactivity
  • VAV2/VAV3 guanine nucleotide exchange factors play a critical role in host-mediated tumor progression and angiogenesis, particularly in tumor endothelium
  • VAV3 function contributes to the timely developmental progression of the cerebellum
  • VAV3 plays important roles in axon branching and growth cone morphology in primary GABAergic cells
  • VAV3 plays a crucial role in prostate cancer growth and malignant behavior
  • VAV2 and VAV3 favor skin tumor initiation and promotion by engaging extracellular signaling loops
  • guanine nucleotide exchange factor VAV3, a regulator of Rho-GTPases, is involved in retinal development
  • is a regulator of retinal progenitor cell differentiation, thus highlighting a novel role for guanine nucleotide exchange factors in retinogenesis
  • is an essential factor in the regulation of osteoclast function
  • may play important roles in the developing nervous system during the differentiation of neural stem cells into the major lineages, namely neurons, oligodendrocytes and astrocytes
  • mediates likely the response of various neural cell types to environmental cues
  • key modulator of GTP-hydrolases of the Rho/Rac family, which are crucially involved in cell proliferation
    a component
    small molecule
  • interacts with the PH domain of APS
  • VAV3, an activator of Rho/Rac GTPases, is an AHR transcriptional target in embryonic fibroblasts
  • novel nuclear function of VAV3 in regulating AR activity
  • VAV3 is a novel TRAF6 interaction partner that functions in the activation of cooperative signaling between TRAF6-binding sites (T6BSs) and the IVVY motif in the TNFRSF11A signaling complex
  • cell & other
    Other regulated by SYK in osteoclasts
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in human prostate cancers
  • to hypertension, diabetes, obesity
  • to Paget disease of bone
  • Variant & Polymorphism other
  • carrier of the T allele in VAV3 rs7528153 polymorphism is associated with a decreased susceptibility of developing a pathologic state composed by the presence of hypertension, diabetes, obesity or cardiovascular damage, and with an increased risk of developing altered basal glycaemia
  • VAV3 rs7528153 polymorphism is a likely susceptibility factor for developing Paget disease of bone
  • Candidate gene
  • VAV3 in peripheral blood may serve as a biomarker for gastric cancer, and to predict the lymphatic metastasis in gastric cancer
  • VAV3 overexpression could be a useful marker for predicting the outcomes of colorectal cancer (CRC) patients
  • Therapy target
    potential new target for antiosteoporosis therapy
    VAV3 targeting represents a potential modality for treating CRC
    VAV3-CDC37 interaction may provide a new therapeutic target in prostate cancer
  • Vav3-deficient mice develop hypertension, tachycardia, and renocardiovascular dysfunctions
  • Vav3-deficient mice exhibit a transient delay in cerebellar development