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FLASH GENE
Symbol VAV1 contributors: mct - updated : 24-01-2015
HGNC name vav 1 guanine nucleotide exchange factor
HGNC id 12657
Location 19p13.3      Physical location : 6.772.721 - 6.857.371
Synonym name
  • vav 1 oncogene
  • vav proto-oncogene
  • Synonym symbol(s) VAV
    DNA
    TYPE functioning gene
    STRUCTURE 84.65 kb     27 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    27 - 2888 - 845 - 2000 10760587
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
     spleen   highly
     thymus   highly
    cell lineage hematopoietic cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • tyrosine phosphorylation at the N-terminus plays a central role in regulating its activity
  • a leucine zipper
  • a helix-loop-helix (HLH)
  • a calponin homology (CH)
  • an atypical C1 domain, which possesses close structural homology to the typical C1 domains of protein kinase C but which fails to bind the second messenger diacylglycerol or the potent analogs, the phorbol esters
  • a ZF domain
  • a DBL homology (DH) interacting with N-terminal helices to exclude and prevent activation of Rho GTPases
  • a pleckstrin homology (PH)
  • one SH2 domains
  • intact C-terminal SH3 domain necessary for VAV1-induced transformation
  • HOMOLOGY
    intraspecies homolog to VAV proto-oncogene 1
    Homologene
    FAMILY
  • DBL family of GDP-GTP exchange factors, VAV family proto-oncogenes
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • GDP-GTP exchange factor (DBL homolog) for Rac or Rho(Arh) proteins (signal transduction)
  • critical transducer of T cell receptor signals to the calcium, ERK and FNKB pathways
  • functions in the hematopoietic system as a specific GDP/GTP nucleotide exchange factor regulated by tyrosine phosphorylation
  • plays a central role in controlling central nervous system immune-mediated disease and proinflammatory cytokine production critical for disease pathogenesis
  • essential signal transducer protein in the hematopoietic system, where it is expressed physiologically
  • guanine nucleotide exchange factor activity is critical for the function of VAV1 as a transforming protein but not for NFAT stimulation
  • its guanine nucleotide exchange activity is required for enhancing BCL2 promoter activity, and the VAV1 downstream substrate, small GTPase RAC2, was likely involved in the control of BCL2 expression
  • hematopoietic cells that is indispensable for transducing the calcium-mobilizing signal
  • VAV1 was originally described as a proto-oncogene of the hematopoietic lineage
  • plays a critical role in hematologic cell signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text T cell and B cell development and activation
    PATHWAY
    metabolism
    signaling signal transduction
    ERK and NFKB
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • co-interacting the activating effect of CD4/LCK in increase of BAX expression
  • ZNF655
  • important interaction with DNM2 that regulates actin reorganization and multiple signaling pathways in T lymphocytes
  • KHDRBS1 is a VAV1 SH3C-associating protein
  • interacting with IDO1 (inhibitory effects of IDO1 on T cell immune responses may be through downregulation of VAV1 protein expression and activation)
  • association with other proteins, detected by SH2 profiling, might affect other VAV1-dependent activities, such as NFAT stimulation
  • NCF2 binding to VAV1 involves their respective PB1 and ZF domains (PMID;
  • interaction of VAV1 with PLCG1 (oncogenic truncation of VAV1 N-terminus elicits conformational changes that interfere with the VAV1-mediated activation of PLCG1 and inhibit calcium mobilization) (PMKID: 22474331)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS