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FLASH GENE
Symbol VAV1 contributors: mct - updated : 24-01-2015
HGNC name vav 1 guanine nucleotide exchange factor
HGNC id 12657
Location 19p13.3      Physical location : 6.772.721 - 6.857.371
Synonym name
  • vav 1 oncogene
  • vav proto-oncogene
  • Synonym symbol(s) VAV
    DNA
    TYPE functioning gene
    STRUCTURE 84.65 kb     27 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC388497 19 LOC388497 MLLT1 19p13.3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 ASAH3 19p13.3 N-acylsphingosine amidohydrolase (alkaline ceramidase) 3 CLPP 19p13.2 ClpP caseinolytic protease, ATP-dependent, proteolytic subunit homolog (E. coli) SPATA11 19p13.3 spermatogenesis associated 11 PSPN 19p13.3 persephin GTF2F1 19p13.3 general transcription factor IIF, polypeptide 1, 74kDa LOC390877 19 similar to adenylate kinase (EC 2.7.4.3), cytosolic - common carp KHSRP 19p13.3 KH-type splicing regulatory protein (FUSE binding protein 2) MGC34725 19p13.3 hypothetical protein MGC34725 MGC2615 19p13.3 hypothetical protein MGC2615 CRB3 19p13.3 crumbs homolog 3 (Drosophila) FLJ22757 TUBB5 19p13.3 tubulin, beta, 5 TNFSF9 19p13.3 tumor necrosis factor (ligand) superfamily, member 9 TNFSF7 19p13 tumor necrosis factor (ligand) superfamily, member 7 LOC390878 19 similar to 60S ribosomal protein L7 TNFSF14 19p13.3 tumor necrosis factor (ligand) superfamily, member 14 C3 19p13.3 complement component 3 GPR108 19p13.3 G protein-coupled receptor 108 TRIP10 19p13.3 thyroid hormone receptor interactor 10 SH2D3A 19p13.3 SH2 domain containing 3A VAV1 19p13.3 vav 1 oncogene EMR1 19p13.3 egf-like module containing, mucin-like, hormone receptor-like sequence 1 EMR4 19p13.3 egf-like module containing, mucin-like, hormone receptor-like 4 LOC284428 19p13.3 similar to methyl-CpG binding domain protein 3-like 2 MBD3L2 19p13.3 methyl-CpG binding domain protein 3-like 2 LOC388498 19 similar to methyl-CpG binding domain protein 3-like 2 MGC4054 19p13.3 hypothetical protein MGC4054 INSR 19p13.3-p13.2 insulin receptor
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    27 - 2888 - 845 - 2000 10760587
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
     spleen   highly
     thymus   highly
    cell lineage hematopoietic cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • tyrosine phosphorylation at the N-terminus plays a central role in regulating its activity
  • a leucine zipper
  • a helix-loop-helix (HLH)
  • a calponin homology (CH)
  • an atypical C1 domain, which possesses close structural homology to the typical C1 domains of protein kinase C but which fails to bind the second messenger diacylglycerol or the potent analogs, the phorbol esters
  • a ZF domain
  • a DBL homology (DH) interacting with N-terminal helices to exclude and prevent activation of Rho GTPases
  • a pleckstrin homology (PH)
  • one SH2 domains
  • intact C-terminal SH3 domain necessary for VAV1-induced transformation
  • HOMOLOGY
    intraspecies homolog to VAV proto-oncogene 1
    Homologene
    FAMILY
  • DBL family of GDP-GTP exchange factors, VAV family proto-oncogenes
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • GDP-GTP exchange factor (DBL homolog) for Rac or Rho(Arh) proteins (signal transduction)
  • critical transducer of T cell receptor signals to the calcium, ERK and FNKB pathways
  • functions in the hematopoietic system as a specific GDP/GTP nucleotide exchange factor regulated by tyrosine phosphorylation
  • plays a central role in controlling central nervous system immune-mediated disease and proinflammatory cytokine production critical for disease pathogenesis
  • essential signal transducer protein in the hematopoietic system, where it is expressed physiologically
  • guanine nucleotide exchange factor activity is critical for the function of VAV1 as a transforming protein but not for NFAT stimulation
  • its guanine nucleotide exchange activity is required for enhancing BCL2 promoter activity, and the VAV1 downstream substrate, small GTPase RAC2, was likely involved in the control of BCL2 expression
  • hematopoietic cells that is indispensable for transducing the calcium-mobilizing signal
  • VAV1 was originally described as a proto-oncogene of the hematopoietic lineage
  • plays a critical role in hematologic cell signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text T cell and B cell development and activation
    PATHWAY
    metabolism
    signaling signal transduction
    ERK and NFKB
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • co-interacting the activating effect of CD4/LCK in increase of BAX expression
  • ZNF655
  • important interaction with DNM2 that regulates actin reorganization and multiple signaling pathways in T lymphocytes
  • KHDRBS1 is a VAV1 SH3C-associating protein
  • interacting with IDO1 (inhibitory effects of IDO1 on T cell immune responses may be through downregulation of VAV1 protein expression and activation)
  • association with other proteins, detected by SH2 profiling, might affect other VAV1-dependent activities, such as NFAT stimulation
  • NCF2 binding to VAV1 involves their respective PB1 and ZF domains (PMID;
  • interaction of VAV1 with PLCG1 (oncogenic truncation of VAV1 N-terminus elicits conformational changes that interfere with the VAV1-mediated activation of PLCG1 and inhibit calcium mobilization) (PMKID: 22474331)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS