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Symbol VAV1 contributors: mct - updated : 24-01-2015
HGNC name vav 1 guanine nucleotide exchange factor
HGNC id 12657
Location 19p13.3      Physical location : 6.772.721 - 6.857.371
Synonym name
  • vav 1 oncogene
  • vav proto-oncogene
  • Synonym symbol(s) VAV
    TYPE functioning gene
    STRUCTURE 84.65 kb     27 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC388497 19 LOC388497 MLLT1 19p13.3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 ASAH3 19p13.3 N-acylsphingosine amidohydrolase (alkaline ceramidase) 3 CLPP 19p13.2 ClpP caseinolytic protease, ATP-dependent, proteolytic subunit homolog (E. coli) SPATA11 19p13.3 spermatogenesis associated 11 PSPN 19p13.3 persephin GTF2F1 19p13.3 general transcription factor IIF, polypeptide 1, 74kDa LOC390877 19 similar to adenylate kinase (EC, cytosolic - common carp KHSRP 19p13.3 KH-type splicing regulatory protein (FUSE binding protein 2) MGC34725 19p13.3 hypothetical protein MGC34725 MGC2615 19p13.3 hypothetical protein MGC2615 CRB3 19p13.3 crumbs homolog 3 (Drosophila) FLJ22757 TUBB5 19p13.3 tubulin, beta, 5 TNFSF9 19p13.3 tumor necrosis factor (ligand) superfamily, member 9 TNFSF7 19p13 tumor necrosis factor (ligand) superfamily, member 7 LOC390878 19 similar to 60S ribosomal protein L7 TNFSF14 19p13.3 tumor necrosis factor (ligand) superfamily, member 14 C3 19p13.3 complement component 3 GPR108 19p13.3 G protein-coupled receptor 108 TRIP10 19p13.3 thyroid hormone receptor interactor 10 SH2D3A 19p13.3 SH2 domain containing 3A VAV1 19p13.3 vav 1 oncogene EMR1 19p13.3 egf-like module containing, mucin-like, hormone receptor-like sequence 1 EMR4 19p13.3 egf-like module containing, mucin-like, hormone receptor-like 4 LOC284428 19p13.3 similar to methyl-CpG binding domain protein 3-like 2 MBD3L2 19p13.3 methyl-CpG binding domain protein 3-like 2 LOC388498 19 similar to methyl-CpG binding domain protein 3-like 2 MGC4054 19p13.3 hypothetical protein MGC4054 INSR 19p13.3-p13.2 insulin receptor
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    27 - 2888 - 845 - 2000 10760587
    Type widely
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
     spleen   highly
     thymus   highly
    cell lineage hematopoietic cell lineage
    cell lines
    at STAGE
  • tyrosine phosphorylation at the N-terminus plays a central role in regulating its activity
  • a leucine zipper
  • a helix-loop-helix (HLH)
  • a calponin homology (CH)
  • an atypical C1 domain, which possesses close structural homology to the typical C1 domains of protein kinase C but which fails to bind the second messenger diacylglycerol or the potent analogs, the phorbol esters
  • a ZF domain
  • a DBL homology (DH) interacting with N-terminal helices to exclude and prevent activation of Rho GTPases
  • a pleckstrin homology (PH)
  • one SH2 domains
  • intact C-terminal SH3 domain necessary for VAV1-induced transformation
    intraspecies homolog to VAV proto-oncogene 1
  • DBL family of GDP-GTP exchange factors, VAV family proto-oncogenes
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
    basic FUNCTION
  • GDP-GTP exchange factor (DBL homolog) for Rac or Rho(Arh) proteins (signal transduction)
  • critical transducer of T cell receptor signals to the calcium, ERK and FNKB pathways
  • functions in the hematopoietic system as a specific GDP/GTP nucleotide exchange factor regulated by tyrosine phosphorylation
  • plays a central role in controlling central nervous system immune-mediated disease and proinflammatory cytokine production critical for disease pathogenesis
  • essential signal transducer protein in the hematopoietic system, where it is expressed physiologically
  • guanine nucleotide exchange factor activity is critical for the function of VAV1 as a transforming protein but not for NFAT stimulation
  • its guanine nucleotide exchange activity is required for enhancing BCL2 promoter activity, and the VAV1 downstream substrate, small GTPase RAC2, was likely involved in the control of BCL2 expression
  • hematopoietic cells that is indispensable for transducing the calcium-mobilizing signal
  • VAV1 was originally described as a proto-oncogene of the hematopoietic lineage
  • plays a critical role in hematologic cell signaling
    text T cell and B cell development and activation
    signaling signal transduction
    ERK and NFKB
    a component
    small molecule
  • co-interacting the activating effect of CD4/LCK in increase of BAX expression
  • ZNF655
  • important interaction with DNM2 that regulates actin reorganization and multiple signaling pathways in T lymphocytes
  • KHDRBS1 is a VAV1 SH3C-associating protein
  • interacting with IDO1 (inhibitory effects of IDO1 on T cell immune responses may be through downregulation of VAV1 protein expression and activation)
  • association with other proteins, detected by SH2 profiling, might affect other VAV1-dependent activities, such as NFAT stimulation
  • NCF2 binding to VAV1 involves their respective PB1 and ZF domains (PMID;
  • interaction of VAV1 with PLCG1 (oncogenic truncation of VAV1 N-terminus elicits conformational changes that interfere with the VAV1-mediated activation of PLCG1 and inhibit calcium mobilization) (PMKID: 22474331)
  • cell & other