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FLASH GENE
Symbol VAT1 contributors: mct - updated : 08-06-2016
HGNC name vesicle amine transport protein 1 homolog (T californica)
HGNC id 16919
Location 17q21.31      Physical location : 41.166.621 - 41.174.459
Synonym name
  • synaptic vesicle membrane protein VAT-1 homolog
  • membrane protein of cholinergic synaptic vesicles
  • Synonym symbol(s) VATI, FLJ20230, VAT-1
    DNA
    TYPE functioning gene
    STRUCTURE 7.84 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked   status
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2758 - 393 - 2003 12898150
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    not specificepithelial cell
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,nucleus
    text synaptic vesicle membrane
    basic FUNCTION playing a role in in keratinocyte physiology, in particular in calcium-regulated processes, with no evident deregulation in malignancies of the breast and ovary
  • is a novel pathogenic factor in Benign prostatic hyperplasia (BPH) associated with cell proliferation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • essential role for GPLD1 in the recruitment of VAT1 to membranes in human neutrophils
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    expression level was higher in both epithelial and stromal cells tissue in benign prostatic hyperplasia (BPH)than in normal prostate
    tumoral     --over  
    in glioblastomas and functionally involved in glioma cell migration, representing a new component involved in glioma invasion
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS