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FLASH GENE
Symbol VASP contributors: mct/npt/pgu - updated : 24-02-2014
HGNC name vasodilator-stimulated phosphoprotein
HGNC id 12652
Location 19q13.32      Physical location : 46.010.687 - 46.030.238
DNA
TYPE functioning gene
STRUCTURE 19.55 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
CLPTM1 19q13.2 cleft lip and palate associated transmembrane protein 1 RELB 19q13.32 v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (avian) SFRS16 19q13.3 splicing factor, arginine/serine-rich 16 (suppressor-of-white-apricot homolog, Drosophila) ZNF342 19q13.32 zinc finger protein 342 GEMIN7 19q13.32 gem (nuclear organelle) associated protein 7 EIF5AP3 19q13.2 eukaryotic translation initiation factor 5A pseudogene 3 LOC284352 19q13.32 hypothetical protein LOC284352 FLJ33600 19q13.32 FLJ33600 protein MGC2650 19q13.32 hypothetical protein MGC2650 LOC388552 19 similar to BC043666 protein XTP7 19q13.32 protein 7 transactivated by hepatitis B virus X antigen (HBxAg) MARK4 19q13.2 MAP/microtubule affinity-regulating kinase 4 CKM 19q13.2 creatine kinase, muscle LOC390943 19 similar to 40S ribosomal protein S16 KLC2L 19q13.3 similar to 40S ribosomal protein S16 ERCC2 19q13.3 excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D) RAI 19q13.32 RelA-associated inhibitor ASE-1 19q13.3 RelA-associated inhibitor ERCC1 19q13.3 excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) FOSB 19q13.3 FBJ murine osteosarcoma viral oncogene homolog B RTN2 19q13.3 reticulon 2 VASP 19q13.2-q13.3 vasodilator-stimulated phosphoprotein FLJ40125 19q13.32 hypothetical protein FLJ40125 OPA3 19q13.32 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) GPR4 19q13.3 G protein-coupled receptor 4 EML2 19q13.32 echinoderm microtubule associated protein like 2 GIPR 19q13.3 gastric inhibitory polypeptide receptor SNRPD2 19q13.2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa FLJ20084 19q13.32 hypothetical protein FLJ20084 20D7-FC4 LOC388553 19 LOC388553 SIX5 19q13.3 sine oculis homeobox homolog 5 (Drosophila) DMPK 19q13.3 dystrophia myotonica-protein kinase DMWD 19q13.3 dystrophia myotonica-containing WD repeat motif RSHL1 19q13.3 radial spokehead-like 1 SYMPK 19q13.32 symplekin
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 2298 - 380 - 1995 7644520
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   highly
Digestiveintestinesmall intestine  highly
Reproductivefemale systemuteruscervix highly
Skin/Tegumentskin   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticplatelet
Cardiovascularendothelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal EVH1 domain binding D/EFPPPPXD motifs and targeting VASP to focal contacts
  • a central proline rich domain binding profilin,
  • SH3, WW domains
  • a C terminal EVH2 oligomerization domain binding F-actin
  • EVH2 domain induces and maintains clustering of the barbed ends of actin filaments, which putatively corresponds to a transition from lamellipodial to filopodial localization
  • EVH1 domain, together with the GAB motif in the EVH2 domain, helps to maintain at the growing barbed ends
  • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY
  • Ena/VASP family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text Vimentin colocalized with VASP and PKG in endothelial cells
    basic FUNCTION
  • involved in cGMP and cAMP mediated inhibition of agonist-induced platelet aggregation
  • by linking profilin to zyxin/p83, VASP may participate in spatially confined profilin-regulated F-actin formation
  • negative regulator of cell motility intracellular histeria lacterium translocation
  • key regulator of dynamic actin structures like filopodia and lamellipodia
  • actin-binding protein that regulates actin polymerization and bundling via direct interaction with both globular (G) and filamentous (F) actin
  • involved in force-mediated adherens junction strengthening
  • have a role beyond anticapping activity in filopodia formation
  • like ZYX, is required for establishment of strong epithelial cell–cell adhesions
  • key actin regulator that localize at regions of dynamic actin remodeling, including cellular protrusions and cell-cell and cell-matrix junctions
  • critical for actin cytoskeleton remodeling events involved in the maintenance of functional endothelia
  • central protein in the control of the alveolar-capillary barrier properties during acute lung injury
  • direct interaction of VASP with CXCR2 is essential for proper CXCR2 function and demonstrate a crucial role for VASP in mediating chemotaxis in leukocytes
  • associates with focal adhesions and areas of dynamic membrane activity and regulates actin polymerization
  • involved in actin polymerization and bundling which is critical for spine formation, expansion, and modulating synaptic strength
  • PI(3,4)P&
  • 8322;, RAPH1, and ENA/VASP are involved in the process movement of multipolar migrating cells 8)
  • can catalyze actin polymerization by elongating actin filaments
  • is a critical regulator of actin dynamics and tension generation during the contractile activation of airway smooth muscle (ASM)
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component associated with actin filaments and focal adhesions which form the interface between cytoskeleton and extracellular matrix
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly binds to APBB1IP and co-localizes with them at lamellipodia tips and at focal adhesions in response to Ras activation
  • CXCR2-interacting protein (interaction between CXCR2 and VASP is direct and enhanced by CXCL8 stimulation, which triggers VASP phosphorylation via PKA- and PKCdelta-mediated pathways)
  • interaction between vimentin and VASP constitutes an important step in endothelial cell migration and proliferation
  • ZYX recruits Enabled/vasodilator-stimulated phospho-proteins (ENAH/VASP) to promote actin assembly
  • interacting with ZYX
  • VASP is a novel substrate for PRKD1(PRKD1 directly phosphorylates VASP at two serine residues, Ser-157 and Ser-322)
  • FBLIM1 is a novel cell-matrix adhesion protein known to interact with VASP and be localized both at cell-matrix and cell-cell adhesions
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    present in apical tight junctions in normal epithelium but were dislocated to the basolateral position in patients with inactive Crohn disease (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS