basic FUNCTION
| involved in cGMP and cAMP mediated inhibition of agonist-induced platelet aggregation |
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by linking profilin to zyxin/p83, VASP may participate in spatially confined profilin-regulated F-actin formation |
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negative regulator of cell motility intracellular histeria lacterium translocation |
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key regulator of dynamic actin structures like filopodia and lamellipodia |
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actin-binding protein that regulates actin polymerization and bundling via direct interaction with both globular (G) and filamentous (F) actin |
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involved in force-mediated adherens junction strengthening |
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have a role beyond anticapping activity in filopodia formation |
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like ZYX, is required for establishment of strong epithelial cell–cell adhesions |
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key actin regulator that localize at regions of dynamic actin remodeling, including cellular protrusions and cell-cell and cell-matrix junctions |
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critical for actin cytoskeleton remodeling events involved in the maintenance of functional endothelia |
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central protein in the control of the alveolar-capillary barrier properties during acute lung injury |
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direct interaction of VASP with CXCR2 is essential for proper CXCR2 function and demonstrate a crucial role for VASP in mediating chemotaxis in leukocytes |
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associates with focal adhesions and areas of dynamic membrane activity and regulates actin polymerization |
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involved in actin polymerization and bundling which is critical for spine formation, expansion, and modulating synaptic strength |
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PI(3,4)P& |
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8322;, RAPH1, and ENA/VASP are involved in the process movement of multipolar migrating cells 8) |
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can catalyze actin polymerization by elongating actin filaments |
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is a critical regulator of actin dynamics and tension generation during the contractile activation of airway smooth muscle (ASM) |
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