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FLASH GENE
Symbol VAMP7 contributors: mct/npt/pgu - updated : 26-06-2015
HGNC name vesicle-associated membrane protein 7
HGNC id 11486
Location Xq28      Physical location : 59.213.948 - 155.173.432
Synonym name
  • tetanus insensitive VAMP (Ti-VAMP)
  • synaptobrevin-like 1
  • Ti- VAMP/VAMP7
  • Synonym symbol(s) TI-VAMP, SYBL1, VAMP-7, TIVAMP
    DNA
    TYPE functioning gene
    STRUCTURE 62.50 kb     8 Exon(s)
    regulatory sequence cytosine-phosphate-guanine/HTF
    text structure inactivated not only on the active X in female but also on the Y chromiosome in male
    MAPPING cloned Y linked N status provisional
    regionally located located in the subtelomeric, long arm of the pseudoautosomal region (PARXQ) in the proximal 295kb, undergoing X (and Y) inactivation (escaping to silencing in ICF syndrome)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2596 - 260 - 2011 21609427
    8 - 2664 - 220 - 2011 21609427
    7 - 2541 - 179 - 2011 21609427
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine    Homo sapiens
    Endocrineparathyroid    
    Nervousbrainlimbic systemhippocampus   Homo sapiens
    Reproductivefemale systemuteruscervix  
    Urinarykidney     Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal domains that can interact with their respective SNARE core domains and thereby affect the kinetics of SNARE complex formation
  • an amphipathic helix which may participate in coiled coil interactions (V-snare coiled-coil homology domain)
  • a longin domain
  • a C terminal hydrophobic domain predicted to serve as a membrane anchor
  • HOMOLOGY
    Homologene
    FAMILY
  • synaptobrevin, V-SNARE protein family
  • CATEGORY transcription factor , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    text
  • VAMP3 and VAMP7 colocalize with the major myelin proteolipid protein (PLP1) in recycling endosomes and late endosomes/lysosomes, respectively
  • ANKRD27, VAMP7 and RAB21 co-localize in the perinuclear region of differentiating hippocampal neurons and transiently in transport vesicles in the shaft of neurites
  • localizes to endosomes and lysosomes but also to the trans-Golgi network
  • localizes to melanosomes and is required for pigmentation and cargo trafficking
  • basic FUNCTION
  • soluble N ethylmaleimide-sensitive factor-attachment protein receptor
  • required with VAMP8 for activation-induced degranulation of mature mast cells
  • enriched in intestinal ER and that it plays a functional role in the delivery of triacylglycerol from the ER to the Golgi
  • mediates exocytosis during neuritogenesis, phagocytosis and lysosomal secretion
  • role in the secretory pathway of a tetraspanin
  • adopts a preferentially closed conformation in solution
  • with other VAMPs, has differential membrane fusion capacities, and imply that with the exception of VAMP5, VAMPs are essentially redundant in mediating fusion with plasma membrane t-SNAREs
  • involvement of VAMP3/cellubrevin and VAMP7/TI-VAMP in myelin membrane trafficking
  • controls exocytosis of PLP1 from late endosomal/lysosomal organelles as part of a transcytosis pathway)
  • involved in multiple cell pathways, including control of neurite outgrowth
  • required in neurons to extend axons to the full extent
  • associates with perforin-containing granules in nonactivated cells, indicating that the two VAMPs have different functions in exocytosis
  • involved in many fusion processes and thus plays a more general function in NK-cell activity than VAMP4
  • unexpected role of VAMP7-mediated vesicular traffic in anxiety, suggesting a role for VAMP7 in higher brain functions
  • role for VAMP7 in pigmentation by trafficking melanosomal cargoes such as TYRP1 from endosomes to maturing melanosomes
  • VAMP7 and TYRP1 traffic to melanosomes in BLOC1S1–dependent membrane tubules
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    text may be involved in lysosomal proteins trafficking
    PATHWAY
    metabolism
    signaling
    a component
  • complex between proteins on endosomes/lysosomes and target membranes
  • SNARE complex containing VAMP7 and VTI1A defines a novel traffic pathway to the cell surface in both neuronal and non-neuronal cells
  • potential role of VAMP7-mediated vesicular traffic in anxiety, suggesting a role in higher brain functions
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with AGFG1 (may interact only during the early stages of endocytosis)
  • required for secretion from the Golgi apparatus to the cell surface, and VAMP7-positive vesicles transport CD82
  • ANKRD27-VAMP7 interaction is essential for the peripheral melanosomal distribution of TYRP1 in melanocytes
  • interacts with ANKRD27, a guanine nucleotide exchange factor (GEF) of the small GTPase RAB21, through a specific domain herein called the interacting domain (ID)
  • SNARE machinery composed of VAMP7 on TYRP1-containing vesicles and STX3 and SNAP23 on melanosomes regulates TYRP1 trafficking to the melanosome in melanocytes
  • PICALM is able to sort VAMP4 and VAMP7, even though they have sorting signals for other clathrin adaptors
  • RELN mobilizes a VAMP7-dependent synaptic vesicle pool and selectively augments spontaneous neurotransmission
  • mutual dependency between STX13 and VAMP7 in regulating their localization for efficient cargo delivery to melanosomes
  • in addition to VAMP7, ANKRD27 binds to RAB32/38
  • HPS4 regulates recycling of VAMP7 from melanosomes, most likely by recruiting RAB38 and consequently ANKRD27 to initiate and/or complete tubule formation
  • cell & other
    REGULATION
    Other DNA methylation plays an essential role for the maintenance of X- and Y-inactivation of SYBL1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS