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FLASH GENE
Symbol VAMP4 contributors: mct - updated : 26-06-2012
HGNC name vesicle-associated membrane protein 4
HGNC id 12645
Location 1q24.3      Physical location : 171.669.297 - 171.711.379
Synonym symbol(s) VAMP24
DNA
TYPE functioning gene
STRUCTURE 39.06 kb     8 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
FLJ11752 1q23.3 NTKL-binding protein 1 PRRX1 1q23-1q25 paired related homeobox 1 LOC391133 1 similar to hypothetical protein BC015183 FMO3 1q23-q24 flavin containing monooxygenase 3 LOC388714 1 similar to Putative dimethylaniline monooxygenase [N-oxide forming] 6 (Flavin-containing monooxygenase 6) (FMO 6) (Dimethylaniline oxidase 6) FMO2 1q23-q25 flavin containing monooxygenase 2 FMO1 1q23-q25 flavin containing monooxygenase 1 PRO1257 1q24.1 hypothetical protein PRO1257 FMO4 1q23-q25 flavin containing monooxygenase 4 HCP3 1q23.3 cytochrome c, somatic pseudogene XTP2 1q23.3 HBxAg transactivated protein 2 MYOC 1q24.3-q25.2 myocilin, trabecular meshwork inducible glucocorticoid response LOC391134 1 similar to Chain  , Profilin LOC391135 1 similar to ribosomal protein L4; 60S ribosomal protein L4; homologue of Xenopus ribosomal protein L1 VAMP4 1q24-q25 vesicle-associated membrane protein 4 LOC391136 1 similar to RNA binding motif protein 3 CGI-01 1q24-q25.3 CGI-01 protein LOC391137 1 similar to dJ612B18.1 (similar to 40S ribosomal protein) LOC127099 1q24.1 similar to 60S ACIDIC RIBOSOMAL PROTEIN P1 KIAA0820 1q24 similar to 60S ACIDIC RIBOSOMAL PROTEIN P1 LOC92346 1q24.1 LOC92346 PIGC 1q23-q25 phosphatidylinositol glycan, class C C1orf9 1q24 chromosome 1 open reading frame 9 TNFSF6 1q23.3 tumor necrosis factor (ligand) superfamily, member 6 LOC391138 1 similar to Multisynthetase complex auxiliary component p43 TNFSF18 1q23 tumor necrosis factor (ligand) superfamily, member 18
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 5152 - 140 - 2003 14608369
8 - 5155 - 141 - 2003 14608369
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumcardiac  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an amphipathic helix which may participate in coiled coil interactions
  • a C terminal hydrophobic domain predicted to serve as a membrane anchor
  • a di-leucine motif required for its localization and AP-1 binding
  • a cytoplasmic domain responsible its correct subcellular targeting
  • HOMOLOGY
    Homologene
    FAMILY
  • synaptobrevin, V-SNARE protein family
  • CATEGORY structural protein , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,vesicle
    text predominantly in the trans-Golgi network
    basic FUNCTION
  • soluble N-ethylmaleimide sensitive attachment protein receptor
  • role in trans-Golgi network to endosome transport
  • R-SNARE that has never been shown to participate in regulated exocytoses, therefore appears to be harboured in the membrane of enlargeosomes and to be a member of the machinery mediating their regulated exocytosis
  • v-SNARE that reside in various post-Golgi vesicular compartments
  • with other VAMPs, has differential membrane fusion capacities, and imply that with the exception of VAMP5, VAMPs are essentially redundant in mediating fusion with plasma membrane t-SNAREs
  • VAMP7 is involved in many fusion processes and thus plays a more general function in NK-cell activity than VAMP4
  • directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text vesicular trafficking
    PATHWAY
    metabolism
    signaling
    a component
  • complex between proteins on vesicle and target membranes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SLC2A4 (requirement for VAMP4 for the initial biosynthetic entry of SLC2A4 from the Golgi apparatus into the insulin-responsive vesicle compartment) (Williams 2008)
  • PICALM is able to sort VAMP4 and VAMP7, even though they have sorting signals for other clathrin adaptors
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS