Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol VAMP3 contributors: mct - updated : 28-03-2018
HGNC name vesicle-associated membrane protein 3 (cellubrevin)
HGNC id 12644
Location 1p36.23      Physical location : 7.831.328 - 7.841.491
Synonym name
  • cellubrevin
  • synaptobrevin 3
  • Synonym symbol(s) CEB, SYB3
    DNA
    TYPE functioning gene
    STRUCTURE 10.16 kb     5 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2225 11.18 100 - 2009 19159614
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticplatelet
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an amphipathic helix which may participate in coiled coil interactions
  • a C terminal hydrophobic domain predicted to serve as a membrane anchor
  • HOMOLOGY
    Homologene
    FAMILY
  • synaptobrevin family
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • v-SNARE that resides in recycling endosomes and endosome-derived transport vesicles
  • VAMP3 and VAMP7 colocalize with the major myelin proteolipid protein (PLP1) in recycling endosomes and late endosomes/lysosomes, respectively
  • basic FUNCTION
  • soluble N ethylmaleimide-sensitive factor-attachment protein receptor, SNARE protein
  • associated with the early endosome, involved in regulating membrane traffic
  • VAMP3 and AP1B1 cooperate in basolateral membrane trafficking
  • implicated in recycling of transferrin receptors, secretion of alpha-granules in platelets, and membrane trafficking during cell migration
  • transport vesicles containing VAMP3 have distinct membrane fusion kinetics with domains of the plasma membrane that present different t-SNARE proteins
  • SNARE protein that mediates exocytosis, in cell migration and integrin trafficking
  • VAMP3-dependent integrin trafficking is crucial in cell migration and cell adhesion to laminin, and VAMP3-mediated integrin trafficking is critical in cell migration and cell adhesion to laminin
  • with other VAMPs, has differential membrane fusion capacities, and imply that with the exception of VAMP5, VAMPs are essentially redundant in mediating fusion with plasma membrane t-SNAREs
  • involvement of VAMP3/cellubrevin and VAMP7/TI-VAMP in myelin membrane trafficking
  • regulates podosome organisation in macrophages and together with STX4/SNAP23 mediates adhesion, cell spreading and persistent migration
  • platelets are capable of a range of endocytosis steps, with VAMP3 being pivotal in these processes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text vesicular trafficking
    PATHWAY
    metabolism
    signaling
  • potential new integrin trafficking pathway in which endocytosed integrins are transported from VAMP3-containing recycling endosomes to STX6-containing trans-Golgi network before being recycled to the plasma membrane
  • a component
  • complex between proteins on vesicle and target membranes
  • VAMP-3 and VAMP-8 forming SNARE complexes with platelet syntaxin 4 and are required for platelet granule secretion
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with BCAP29
  • with SNAP23 and STX12, have a role in the trafficking of MMP during degradation of ECM substrates and subsequent cellular invasion
  • regulates podosome organisation in macrophages and together with STX4/SNAP23 mediates adhesion, cell spreading and persistent migration
  • RNF130 ubiquitin ligases play a novel role in regulating recycling endosome trafficking via ubiquitylation of the VAMP3 SNARE protein
  • PI4K2A is a binding partner of vesicle-associated membrane protein 3 (VAMP3), a small R-SNARE involved in recycling and retrograde transport, and the two proteins co-reside on tubulo-vesicular endosomes
  • small GTPase RAB8A interacts with VAMP3 to regulate the delivery of recycling T-cell receptors to the immune synapse
  • VAMP3 interacts with SLC12A1 and mediates its constitutive exocytic delivery to the apical surface, and VAMP3 is required for normal SLC12A1 expression, renal function, and blood pressure
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    silencing inhibits cell adhesion to laminin and effectively reduced cell motility
    constitutional     --over  
    protects cardiac glucose metabolism under conditions of impaired insulin sensitivity
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Vamp3-/- mice had less platelet-associated Fg, indicating a defect in Fg uptake/storage