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FLASH GENE
Symbol VAMP2 contributors: mct/npt/pgu - updated : 30-06-2012
HGNC name vesicle-associated membrane protein 2 (synaptobrevin 2)
HGNC id 12643
Location 17p13.1      Physical location : 8.062.464 - 8.066.293
Synonym name synaptobrevin 2
Synonym symbol(s) SYB2, FLJ11460, VAMP-2
DNA
TYPE functioning gene
STRUCTURE 3.83 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map pter - D17S849 - D17S1828 - D17S1298 - D17S1537 - D17S938 - VAMP2 - D17S786 - cen
Authors PMID: 10965122
Physical map
FLJ46675 17p13.2 FLJ46675 protein KIAA0346 17p13.1-p12 FLJ46675 protein LOC92162 17p13.2 similar to RIKEN cDNA 2600017H02 MGC14151 17p13.2 hypothetical protein MGC14151 FLJ32499 17p13.2 hypothetical protein FLJ32499 LOC388331 17 LOC388331 KCNAB3 17p13.1 potassium voltage-gated channel, shaker-related subfamily, beta member 3 TRAPPC1 17p13.1 trafficking protein particle complex 1 LIP8 17p13.2 LYST-interacting protein LIP8 GUCY2D 17p13.1 guanylate cyclase 2D, membrane (retina-specific) ALOX15B 17p13.1 arachidonate 15-lipoxygenase, second type LOC388332 17 similar to Gag protein ALOX12B 17p13.1 arachidonate 12-lipoxygenase, 12R type ALOXE3 17p13.1 arachidonate lipoxygenase 3 HES7 17p13.1 hairy and enhancer of split 7 (Drosophila) PER1 17p13.1-p12 period homolog 1 (Drosophila) VAMP2 17p13.1-p12 vesicle-associated membrane protein 2 (synaptobrevin 2) MGC10744 17p13.1 hypothetical protein MGC10744 FLJ20014 17p13.1 hypothetical protein FLJ20014 AURKB 17p13.1 aurora kinase B FLJ34790 17p13.1 hypothetical protein FLJ34790 FLJ22170 17p13.1 hypothetical protein FLJ22170 PFAS 17p13 phosphoribosylformylglycinamidine synthase (FGAR amidotransferase) RANGNRF 17p13 RAN guanine nucleotide release factor ARHGEF15 17p12 Rho guanine nucleotide exchange factor (GEF) 15 ODF4 17p12 outer dense fiber of sperm tails 4 LOC124751 17p13.1 hypothetical protein LOC124751 RPL26 17p13 ribosomal protein L26 LOC390761 17 similar to RIKEN cDNA 9930039A11 gene NDEL1 17p13.1 nudE nuclear distribution gene E homolog like 1 (A. nidulans)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 2173 - 116 - 2008 18182011
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainhindbrainponstrigeminal ganglia 
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticplatelet
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal half of the SNARE motif of VAMP2 serves as a sorting determinant for recognition by the related ANTH domain-containing endocytic adaptor
  • C terminus with a potential role in fusion pore formation
  • secondary structure one alpha helix contributing to the four helix bundle of synaptic SNARE complex
    HOMOLOGY
    Homologene
    FAMILY
  • synaptobrevin family
  • CATEGORY regulatory , structural protein , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,granule
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • fusion of synaptic vesicles to target membranes
  • VAMP1 and VAMP2, both co-sediment and co-localize with NPPA
  • colocalized with CPLX2 along the apical plasma membrane following cholecystokinin-8 stimulation
  • SEMA3A receptor and VAMP2 colocalize in endosomal membranes
  • basic FUNCTION
  • soluble N ethylmaleimide-sensitive factor-attachment protein receptor, SNARE protein
  • calcium dependent role in the docking and fusion of synaptic vesicles with the presynaptic membrane
  • role for both myosin Va and VAMP2 in oligodendrocyte function as it relates to myelination
  • playing a central role in neural exocytosis
  • regulate GLUT4 trafficking in slow-twitch myofibers in soleus muscle and neurotransmitter release in nerve endings
  • plays roles in quiescent satellite cells and is involved in muscle regeneration
  • VAMP2 mediates the trafficking of alpha5beta1 integrin to the plasma membrane and VAMP2-dependent integrin trafficking is critical in cell adhesion, migration and survival
  • with VAMP1, and syntaxin-4 regulate NPPA release from cardiac myocyte
  • with other VAMPs, has differential membrane fusion capacities, and imply that with the exception of VAMP5, VAMPs are essentially redundant in mediating fusion with plasma membrane t-SNAREs
  • essential for T3 to increase insulin-stimulated translocation of SLC2A4 and subsequent uptake of glucose in adipocytes
  • most abundant synaptic vesicle protein, required for fast calcium-triggered synaptic vesicle fusion
  • SEMA3A-mediated signaling and axonal repulsion require VAMP2-dependent vesicular traffic
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of a synaptic core complex with syntaxin and synaptosome associated proteins (SNAP25)
  • critical component of the synaptic vesicle--fusion machinery
  • three SNAREs, STX4, VAMP1 and VAMP2, form a SNARE complex inside cardiac myocytes
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • binding to t-SNARES, syntaxin (STXs) and SNAP25 after the fusion of synaptic vesicles to plasma membrane
  • interacting with PRKD3 (may regulate VAMP2 vesicle trafficking by facilitating its recruitment to the target membrane)
  • interacting with PICALM (facilitates the endocytosis of the synaptic vesicle protein VAMP2 from the plasma membrane)
  • association of VAMP2 with synaptophysin I in the specification of the pathway of synaptic vesicle biogenesis
  • interacting with SLC2A4 (VAMP2 required for sorting to the specialized insulin-responsive compartment after plasma membrane endocytosis)
  • VAMP2 is interaction partner of WDFY2 (with VAMP2, WDFY2 may be involved in vesicle cycling in various secretory pathway)
  • interaction of STXBP4 with STX4 prevents interaction of VAMP2 located in SLC2A4 vesicle with STX4 in basal state
  • interacts with SNAP-25 and syntaxin-1 to form a stable SNARE complex
  • modulates KCNB1 inactivation by interfering with the interaction between the docking loop and C1a, a mechanism for gating regulation that may pertain also to other Kv channels
  • interacting with STXBP5 (tail domain of STXBP5 controlled membrane fusion though STXBP5 displacement by VAMP2)
  • CPLX2 interact with vesicle-associated membrane protein (VAMP2), syntaxins 3 and 4, but not with VAMP8 or syntaxin 2
  • PICALM controls the level of the synaptic vesicle protein VAMP2 at the plasma membrane by regulating VAMP2 endocytosis
  • associated with Neuropilin 1 (NRP1) and PLXNA1, two essential components of the SEMA3A receptor, via its juxtatransmembrane domain
  • cell & other
  • targeted to renin-containing granules and mediates the stimulatory effect of cAMP on renin exocytosis
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS