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Symbol UXT contributors: mct - updated : 03-09-2015
HGNC name ubiquitously-expressed transcript
HGNC id 12641
Location Xp11.23      Physical location : 47.511.195 - 47.518.560
Synonym name
  • SKP2-associated alpha PFD 1
  • androgen receptor trapped clone 27 protein; protein
  • Synonym symbol(s) ART-27, RP1-212G6.2, STAP1
    TYPE functioning gene
    STRUCTURE 7.39 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked   status provisional
    Physical map
    RP2 Xp11.23 retinitis pigmentosa 2 (X-linked recessive) PHF16 Xp11.3-p11.23 PHD finger protein 16 RGN Xp11.3-q11.2 regucalcin (senescence marker protein-30) RNU12 Xp11.3 RNA, U12 small nuclear P17.3 Xp11.3 neuronal protein 17.3 RBM10 Xp11.23 RNA binding motif protein 10 UBE1 Xp11.23 ubiquitin-activating enzyme E1 (A1S9T and BN75 temperature sensitivity complementing) INE1 Xp11.4-p11.3 inactivation escape 1 PCTK1 Xp11.3 PCTAIRE protein kinase 1 USP11 Xp21.2-p11.2 ubiquitin specific protease 11 ZNF157 Xp11.23 zinc finger protein 157 (HZF22) ZNF41 Xp11.23 zinc finger protein 41 LOC389850 X similar to hypothetical protein, MGC:7199 TIMP1 Xp11.23 tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor) ARAF1 Xp11.3-p11.23 v-raf murine sarcoma 3611 viral oncogene homolog 1 SYN1 Xp11.23 synapsin I PFC Xp11.3-p11.23 properdin P factor, complement ELK1 Xp11.3-p11.23 ELK1, member of ETS oncogene family UXT Xp11.23-p11.22 ubiquitously-expressed transcript LOC392458 X similar to spermine synthase; spermidine aminopropyltransferase LOC392459 X similar to CpG binding protein (Protein containing PHD finger and CXXC domain 1) LOC286404 Xp11.3 hypothetical gene supported by NM_006990; AB026542 LOC389851 X similar to Itchy homolog E3 ubiquitin protein ligase (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1) LOC347344 Xp11.3 similar to Zinc finger protein 81 (HFZ20) ZNF21 Xp11.23 zinc finger protein 21 (KOX 14) LOC389852 X similar to dJ54B20.3 (novel protein similar to lysozyme C (1,4-beta-N-acetylmuramidase)) FLJ20573 Xp11.3-p11.1 hypothetical zinc finger protein FLJ20573 SSX6 Xp11.2 synovial sarcoma, X breakpoint 6 psiSSX2 Xp11.2 SSX2 pseudogene LOC389853 X similar to dJ54B20.3 (novel protein similar to lysozyme C (1,4-beta-N-acetylmuramidase)) LOC392460 X similar to Ornithine aminotransferase, mitochondrial precursor (Ornithine--oxo-acid aminotransferase) psiSSX3 Xp11.2 SSX3 pseudogene SSX5 Xp11.2-p11.1 synovial sarcoma, X breakpoint 5 LOC392462 X similar to synovial sarcoma, X breakpoint 6 SSX1 Xp11.23-p11.22 synovial sarcoma, X breakpoint 1 psiSSX8 Xp11.2 psiSSX8 pseudogene SSX9 Xp11.23 synovial sarcoma, X breakpoint 9 psiSSX9 Xp11.2 SSX9 pseudogene SSX3 Xp11.2-p11.1 synovial sarcoma, X breakpoint 3 SSX4 Xp11.2-p11.1 synovial sarcoma, X breakpoint 4
    regionally located 5' to ELK1, subject to X inactivation
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 797 - 169 - 2012 22131337
  • UXT-V1
  • N-terminal TRAF-binding motif of UXT-V1 binds to the C-terminal TRAF domain of TRAF3, thus facilitating the interaction between TRAF3 and MAVS
  • novel regulator of TNF-induced apoptosis and sheds new light on the underlying molecular mechanism of this process
  • represents a novel integral component of the MAVS signalosome on mitochondria, mediating the innate antiviral signal transduction
  • 7 - 619 - 157 ubiquitously expressed 2011 21307340
  • UXT-V2
  • transcriptional cofactor to regulate nuclear factor-KB in the nucleus
    Type widely
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Reproductivemale systemprostate   
    Skin/Tegumentskin   highly
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    cell lineage
    cell lines
    at STAGE
    physiological period pregnancy
    Text placenta
    three potential phosphorylation sit
    interspecies homolog to murine Uxt
    homolog to C.elegans H20J04.5
    intraspecies homolog to no
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
  • initially was dispersed in the extranuclear cytosol, then appeared in punctate cytosolic dots, then an intense perinuclear aggregation that eventually invaded and disrupted the nucleus (Moss 2007)
  • basic FUNCTION
  • involving in tumorigenesis
  • playing a role in facilitating receptor-induced transcriptional activation
  • component of centrosome, essential for cell viability and that may facilitate transformation by corrupting regulated centrosome functions
  • have cytosolic functions, such as a component of the centrosome and in the transportation of mitochondria
  • suppressor of cell transformation, and nuclear factor-KB coregulator
  • integral component of the NF-kappaB enhanceosome and is essential for its nuclear function, which uncovers a new mechanism of NF-kappaB regulation
  • suppresses cell transformation and might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like EVI1
  • EZH1 and SUZ12 act as positive regulators for NFKB1 signaling, demonstrating that EZH1, SUZ12 and UXT work synergistically to regulate pathway activation in the nucleus
    a component
  • forms a dynamic complex with NF-kappaB and is recruited to the NF-kappaB enhanceosome upon stimulation
    small molecule
  • with the AR (AF1a and AF1b activation function) increasing the transcriptional activity of AR
  • associated with gamma-tubulin
  • novel interacting partner of DH/PH domain of ALS2 protein (ALS2 and UXT transcriptional levels are directly correlated through cell cycle)
  • UXT is a cofactor of FOXP3 and an important player in Treg-cell function
  • EZH1 physically interacts with UXT, a small chaperon-like transcription co-activator
  • cell & other
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    contributes to progressive aggregation of mitochondria and cell death potentially through association of UXT with LRPPRC (Moss 2007)
    Variant & Polymorphism
    Candidate gene
    Therapy target