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FLASH GENE
Symbol UXT contributors: mct - updated : 03-09-2015
HGNC name ubiquitously-expressed transcript
HGNC id 12641
Location Xp11.23      Physical location : 47.511.195 - 47.518.560
Synonym name
  • SKP2-associated alpha PFD 1
  • androgen receptor trapped clone 27 protein; protein
  • Synonym symbol(s) ART-27, RP1-212G6.2, STAP1
    DNA
    TYPE functioning gene
    STRUCTURE 7.39 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked   status provisional
    Physical map
    RP2 Xp11.23 retinitis pigmentosa 2 (X-linked recessive) PHF16 Xp11.3-p11.23 PHD finger protein 16 RGN Xp11.3-q11.2 regucalcin (senescence marker protein-30) RNU12 Xp11.3 RNA, U12 small nuclear P17.3 Xp11.3 neuronal protein 17.3 RBM10 Xp11.23 RNA binding motif protein 10 UBE1 Xp11.23 ubiquitin-activating enzyme E1 (A1S9T and BN75 temperature sensitivity complementing) INE1 Xp11.4-p11.3 inactivation escape 1 PCTK1 Xp11.3 PCTAIRE protein kinase 1 USP11 Xp21.2-p11.2 ubiquitin specific protease 11 ZNF157 Xp11.23 zinc finger protein 157 (HZF22) ZNF41 Xp11.23 zinc finger protein 41 LOC389850 X similar to hypothetical protein, MGC:7199 TIMP1 Xp11.23 tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor) ARAF1 Xp11.3-p11.23 v-raf murine sarcoma 3611 viral oncogene homolog 1 SYN1 Xp11.23 synapsin I PFC Xp11.3-p11.23 properdin P factor, complement ELK1 Xp11.3-p11.23 ELK1, member of ETS oncogene family UXT Xp11.23-p11.22 ubiquitously-expressed transcript LOC392458 X similar to spermine synthase; spermidine aminopropyltransferase LOC392459 X similar to CpG binding protein (Protein containing PHD finger and CXXC domain 1) LOC286404 Xp11.3 hypothetical gene supported by NM_006990; AB026542 LOC389851 X similar to Itchy homolog E3 ubiquitin protein ligase (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1) LOC347344 Xp11.3 similar to Zinc finger protein 81 (HFZ20) ZNF21 Xp11.23 zinc finger protein 21 (KOX 14) LOC389852 X similar to dJ54B20.3 (novel protein similar to lysozyme C (1,4-beta-N-acetylmuramidase)) FLJ20573 Xp11.3-p11.1 hypothetical zinc finger protein FLJ20573 SSX6 Xp11.2 synovial sarcoma, X breakpoint 6 psiSSX2 Xp11.2 SSX2 pseudogene LOC389853 X similar to dJ54B20.3 (novel protein similar to lysozyme C (1,4-beta-N-acetylmuramidase)) LOC392460 X similar to Ornithine aminotransferase, mitochondrial precursor (Ornithine--oxo-acid aminotransferase) psiSSX3 Xp11.2 SSX3 pseudogene SSX5 Xp11.2-p11.1 synovial sarcoma, X breakpoint 5 LOC392462 X similar to synovial sarcoma, X breakpoint 6 SSX1 Xp11.23-p11.22 synovial sarcoma, X breakpoint 1 psiSSX8 Xp11.2 psiSSX8 pseudogene SSX9 Xp11.23 synovial sarcoma, X breakpoint 9 psiSSX9 Xp11.2 SSX9 pseudogene SSX3 Xp11.2-p11.1 synovial sarcoma, X breakpoint 3 SSX4 Xp11.2-p11.1 synovial sarcoma, X breakpoint 4
    regionally located 5' to ELK1, subject to X inactivation
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 797 - 169 - 2012 22131337
  • UXT-V1
  • N-terminal TRAF-binding motif of UXT-V1 binds to the C-terminal TRAF domain of TRAF3, thus facilitating the interaction between TRAF3 and MAVS
  • novel regulator of TNF-induced apoptosis and sheds new light on the underlying molecular mechanism of this process
  • represents a novel integral component of the MAVS signalosome on mitochondria, mediating the innate antiviral signal transduction
  • 7 - 619 - 157 ubiquitously expressed 2011 21307340
  • UXT-V2
  • transcriptional cofactor to regulate nuclear factor-KB in the nucleus
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Reproductivemale systemprostate   
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    three potential phosphorylation sit
    HOMOLOGY
    interspecies homolog to murine Uxt
    homolog to C.elegans H20J04.5
    intraspecies homolog to no
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    text
  • initially was dispersed in the extranuclear cytosol, then appeared in punctate cytosolic dots, then an intense perinuclear aggregation that eventually invaded and disrupted the nucleus (Moss 2007)
  • basic FUNCTION
  • involving in tumorigenesis
  • playing a role in facilitating receptor-induced transcriptional activation
  • component of centrosome, essential for cell viability and that may facilitate transformation by corrupting regulated centrosome functions
  • have cytosolic functions, such as a component of the centrosome and in the transportation of mitochondria
  • suppressor of cell transformation, and nuclear factor-KB coregulator
  • integral component of the NF-kappaB enhanceosome and is essential for its nuclear function, which uncovers a new mechanism of NF-kappaB regulation
  • suppresses cell transformation and might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like EVI1
  • EZH1 and SUZ12 act as positive regulators for NFKB1 signaling, demonstrating that EZH1, SUZ12 and UXT work synergistically to regulate pathway activation in the nucleus
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms a dynamic complex with NF-kappaB and is recruited to the NF-kappaB enhanceosome upon stimulation
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with the AR (AF1a and AF1b activation function) increasing the transcriptional activity of AR
  • associated with gamma-tubulin
  • novel interacting partner of DH/PH domain of ALS2 protein (ALS2 and UXT transcriptional levels are directly correlated through cell cycle)
  • UXT is a cofactor of FOXP3 and an important player in Treg-cell function
  • EZH1 physically interacts with UXT, a small chaperon-like transcription co-activator
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    contributes to progressive aggregation of mitochondria and cell death potentially through association of UXT with LRPPRC (Moss 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS