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FLASH GENE
Symbol UTY contributors: mct - updated : 29-12-2016
HGNC name ubiquitously transcribed tetratricopeptide repeat gene, Y-linked
HGNC id 12638
Location Yq11.221      Physical location : 15.360.262 - 15.592.550
Synonym name
  • ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome
  • ubiquitous TPR motif protein UTY
  • Synonym symbol(s) DKFZp686L12190, UTY1, KDM6AL, KDM6C1, KDM6C
    EC.number 1.14.11.-
    DNA
    TYPE functioning gene
    STRUCTURE 249.90 kb     28 Exon(s)    single Copie(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC392590 Y similar to RCC1-like ASSP6 Yq11.22 argininosuccinate synthetase pseudogene 6 ADLICANP Yq11.21 adlican pseudogene RPS24P1 Yq11.23 ribosomal protein S24 pseudogene 1 LOC386726 ARSEP Yq11.2 arylsulfatase E pseudogene ARSDP Yq11.2 arylsulfatase D pseudogene GYG2P Yq11.23 glycogenin 2 pseudogene APXLP Yq11.23 apical protein-like (Xenopus laevis) pseudogene LOC359791 Yq11.1 cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa pseudogene TTTY15 Yq11.1 testis-specific transcript, Y-linked 15 USP9Y Yq11.23 ubiquitin specific protease 9, Y chromosome (fat facets-like Drosophila) CDY4P Yq11.2 chromodomain protein, Y-linked 4 pseudogene DDX3Y Yq11.11-q11.21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked CASKP Yq11 calcium/calmodulin-dependent serine protein kinase (MAGUK family) pseudogene SFPQP Yq11.23 splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) pseudogene UTY Yq11.1-q11.21 ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome PSMA6P Yq11.1 proteasome (prosome, macropain) subunit, alpha type, 6 pseudogene TMSB4Y Yq11.1-q11.22 thymosin, beta 4, Y chromosome LOC360022 Yq11 PC4 and SFRS1 interacting protein 2 pseudogene KALP Yq11.21 Kallmann syndrome sequence pseudogene VCY Yq11.21 variable charge, Y chromosome NLGN4Y Yq11.21 neuroligin 4, Y linked LOC359793 Yq11.21 hypothetical protein FLJ10842 pseudogene HCP46 Yq11.221 cytochrome c, somatic pseudogene FAM16AY Y family with sequence similarity 16, member A, Y-linked
    regionally located in a AZF deleted region
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    28 splicing 4334 - 1079 - 2007 17452356
    28 splicing 4931 - 1240 - 2007 17452356
    28 splicing 6538 - 1347 - 2007 17452356
    28 - 6118 - 1211 - 2007 17452356
    27 - 6355 - 1290 - 2007 17452356
    27 - 6490 - 1335 - 2007 17452356
    28 - 6403 - 1306 - 2007 17452356
    28 - 6586 - 1367 - 2007 17452356
    28 - 6106 - 1207 - 2007 17452356
    28 - 6154 - 1223 - 2007 17452356
    29 - 6289 - 1268 - 2007 17452356
    30 - 6445 - 1320 - 2007 17452356
    28 - 6478 - 1331 - 2007 17452356
    24 - 6277 - 1264 - 2007 17452356
    29 - 6613 - 1376 - 2007 17452356
    29 - 6661 - 1392 - 2007 17452356
    29 - 6616 - 1377 - 2007 17452356
    29 - 6652 - 1389 - 2007 17452356
    29 - 6682 - 1399 - 2007 17452356
    30 - 6817 - 1444 - 2007 17452356
    29 - 6574 - 1363 - 2007 17452356
    - - 6541 - 1342 - 2007 17452356
    - - 6304 - 1263 - 2007 17452356
    - - 6394 - 1293 - 2007 17452356
    - - 6169 - 1218 - 2007 17452356
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • five tetratricopeptide motis
  • HOMOLOGY
    interspecies homolog to murine Uty
    homolog to C.elegans d2021.1
    intraspecies paralog to KDM6A
    Homologene
    FAMILY
  • UTX family
  • CATEGORY enzyme , antigen
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • minor histocompatibility antigen which may induce graft rejection of male stem cell grafts
  • lacking detectable demethylase activity, compensates for the loss of KDM6A in regulating Brachyury expression
  • catalyzes demethylation of H3K27 peptides, analogously to KDM6B and KDM6A, but with reduced activity, due to point substitutions involved in substrate binding
  • NKX3.1-G9a-UTY transcriptional regulatory network is essential for prostate differentiation, and likely disruption of such a network predisposes to prostate cancer
  • both KDM6A and UTY function as dose-dependent suppressors of urothelial bladder cancer (UBC) development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense , reproduction/sex
    text anti-pathogen response ; male specific development, spermatogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with TLE1 and TLE2
  • KDM6A controls mesoderm differentiation and Brachyury (T) expression independent of H3K27 demethylase activity, suggesting that KDM6A and UTY are functionally redundant in ES cell differentiation and early embryonic development
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS