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FLASH GENE
Symbol UTS2 contributors: mct - updated : 20-03-2013
HGNC name urotensin 2
HGNC id 12636
Location 1p36.23      Physical location : 7.907.672 - 7.913.551
Synonym name urotensin-II
Synonym symbol(s) U-II, UCN2, PRO1068, UNQ525
DNA
TYPE functioning gene
STRUCTURE 5.88 kb     5 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC388592 1 similar to Transcription factor HES-2 (Hairy and enhancer of split 2) ESPN 1p36.31-p36.11 espin TNFRSF25 1p36.2 tumor necrosis factor receptor superfamily, member 25 KIAA0720 1p36.23 tumor necrosis factor receptor superfamily, member 25 FLJ23323 1p36.23 hypothetical protein FLJ23323 TAS1R1 1p36.23 taste receptor, type 1, member 1 HKR3 1p36.31 GLI-Kruppel family member HKR3 KIAA0469 1p36.23 KIAA0469 gene product PHF13 1p36.23 PHD finger protein 13 MGC33488 1p36.23 hypothetical protein MGC33488 FLJ10737 1p36.23 hypothetical protein FLJ10737 CAMTA1 1p36.31-p36.23 calmodulin binding transcription activator 1 VAMP3 1pter-p36.32 vesicle-associated membrane protein 3 (cellubrevin) PER3 1p36 period homolog 3 (Drosophila) UTS2 1p36 urotensin 2 TNFRSF9 1p36 tumor necrosis factor receptor superfamily, member 9 PARK7 1p36.33-p36.12 Parkinson disease (autosomal recessive, early onset) 7 MIG-6 1p36.12-36.33 mitogen-inducible gene 6 LOC390993 1 similar to 60S ribosomal protein L7a (Surfeit locus protein 3) (PLA-X polypeptide) DNB5 1p36.2-p36.1 deleted in neuroblastoma 5 RERE 1p36.1-p36.2 arginine-glutamic acid dipeptide (RE) repeats DKFZp566H0824 1p36.22 hypothetical protein DKFZp566H0824 LOC390994 1 similar to 60S ribosomal protein L23a ENO1 1p36.2 enolase 1, (alpha) LOC148915 1p36.22 hypothetical LOC148915 CA6 1p36.2 carbonic anhydrase VI LOC390995 1 similar to Solute carrier family 2, facilitated glucose transporter, member 5 (Glucose transporter type 5, small intestine) (Fructose transporter) SLC2A5 1p36.2 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 GPR157 1p36.22 G protein-coupled receptor 157 H6PD 1p36.3 hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) SSB1 1p36.22 SPRY domain-containing SOCS box protein SSB-1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 584 12 124 - 2009 19001524
5 - 648 14 139 - 2009 19001524
shorter isoform
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel     Homo sapiens
Reproductivemale systemmale genital tract    Homo sapiensAdult
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • urotensin-2 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • acting as a vasoconstrictor
  • contributing to diseases including atherosclerosis, cardiac hypertrophy, pulmonary hypertension and tumour growth
  • vasoactive cyclic neuropeptide which activates the G protein-coupled receptor UTS2R, exerts various cardiovascular effects and may play a role in the pathophysiology of atherosclerosis
  • chemoattractant for UTS2R-expressing monocytes and indicate a pivotal role of the RhoA-Rho kinase signaling cascade in the chemotaxis induced by UTS2
  • having a major role in the pathophysiology of aldosterone-producing adenoma and pheochromocytoma and particularly in a subset of them that have been causally associated with primary aldosteronism
  • having a role in the paracrine interactions between the adrenal medulla and cortex
  • having a role in the pathogenesis and progression of cardiovascular disease
  • intrahepatic UTS2/UTS2R system has an important pathophysiological role in cirrhosis and portal hypertension
  • potential role in glucose homeostasis and diabetes
  • vasoactive peptide associated with vascular remodeling in different cardiovascular disorders
  • involved in the TGFB1 mediated mitogenic effect on airway smooth muscle cells
  • most potent vasoconstrictor, having both vasoconstrictor and vasodilatory actions, and both profibrotic and antiapoptotic activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • signals through a G-protein coupled receptor (GPCR) known as GPR14 or UTS2R
  • UTS2 and NOX4 stimulated FOXO3 activity and MMP2 is a target gene of FOXO3
  • FOXO3 is important for basal and UTS2-stimulated proliferation and vascular outgrowth
  • UTS2 and UCN stimulate the expression of MSTN (
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in patients with heart failure and in patients with renal diseases
    constitutional     --over  
    of TAC3 and UTS2 in the plasma of pre-eclamptic women
    Susceptibility
  • to NIDDM
  • to myocardial infarction in individuals with or without conventional coronary risk factors
  • Variant & Polymorphism other
  • S89N polymorphism is associated with the development of type 2 diabetes, via insulin sensitivity, in Japanese subjects
  • polymorphisms associated with myocardial infarction in individuals with or without conventional coronary risk factors
  • Candidate gene
    Marker
  • important marker of severity of portal hypertension in children
  • Therapy target
    SystemTypeDisorderPubmed
    miscelleaneousurinary 
    UTS2/UTS2R pathway may represent a novel therapeutical target in erectile dysfunction
    digestiveliver 
    potential therapeutic target in the chronic liver disease
    ANIMAL & CELL MODELS
  • 2DM mice showed increased Uts2/Uts2r content, in skeletal muscle