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FLASH GENE
Symbol UTP23 contributors: mct/npt - updated : 31-05-2012
HGNC name UTP23, small subunit (SSU) processome component, homolog (yeast)
HGNC id 28224
Location 8q24.11      Physical location : 117.778.741 - 117.786.919
Synonym name
  • chromosome 8 open reading frame 53
  • rRNA-processing protein UTP23 homolog
  • Synonym symbol(s) C8orf53, MGC14595
    DNA
    TYPE functioning gene
    STRUCTURE 5.46 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3693 28.3 249 - Bleichert (2006)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Skin/Tegumentskin   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies homolog to to the PINc domain protein FCF1
    Homologene
    FAMILY
  • UTP23/FCF1 family
  • UTP23 subfamily
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • involved in rRNA processing
  • essential nucleolar proteins required for the first three cleavage steps in 18S rRNA maturation (Bleichert 2006)
  • required for dissociation of snR30 small nucleolar RNP from preribosomal particles
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to colorectal cancer (CRC)
    Variant & Polymorphism other genetic variation associated with CRC
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS